| http://purl.uniprot.org/citations/28669545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28669545 | http://www.w3.org/2000/01/rdf-schema#comment | "The synaptic adhesion molecules Neurexin and Neuroligin alter the development and function of synapses and are linked to autism in humans. In C. elegans, post-synaptic Neurexin (NRX-1) and pre-synaptic Neuroligin (NLG-1) mediate a retrograde synaptic signal that inhibits acetylcholine (ACh) release at neuromuscular junctions. Here, we show that the retrograde signal decreases ACh release by inhibiting the function of pre-synaptic UNC-2/CaV2 calcium channels. Post-synaptic NRX-1 binds to an auxiliary subunit of pre-synaptic UNC-2/CaV2 channels (UNC-36/α2δ), decreasing UNC-36 abundance at pre-synaptic elements. Retrograde inhibition is mediated by a soluble form of NRX-1's ectodomain, which is released from the post-synaptic membrane by the SUP-17/ADAM10 protease. Mammalian Neurexin-1α binds α2δ-3 and decreases CaV2.2 current in transfected cells, whereas Neurexin-1α has no effect on CaV2.2 reconstituted with α2δ-1 and α2δ-2. Collectively, these results suggest that α-Neurexin binding to α2δ is a conserved mechanism for regulating synaptic transmission."xsd:string |
| http://purl.uniprot.org/citations/28669545 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2017.06.018"xsd:string |
| http://purl.uniprot.org/citations/28669545 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/28669545 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/28669545 | http://purl.uniprot.org/core/author | "Hu Z."xsd:string |
| http://purl.uniprot.org/citations/28669545 | http://purl.uniprot.org/core/author | "Kaplan J.M."xsd:string |
| http://purl.uniprot.org/citations/28669545 | http://purl.uniprot.org/core/author | "Lipscombe D."xsd:string |
| http://purl.uniprot.org/citations/28669545 | http://purl.uniprot.org/core/author | "Nedelcu D."xsd:string |
| http://purl.uniprot.org/citations/28669545 | http://purl.uniprot.org/core/author | "Tong X.J."xsd:string |
| http://purl.uniprot.org/citations/28669545 | http://purl.uniprot.org/core/author | "Lopez-Soto E.J."xsd:string |
| http://purl.uniprot.org/citations/28669545 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28669545 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/28669545 | http://purl.uniprot.org/core/pages | "326-340.e5"xsd:string |
| http://purl.uniprot.org/citations/28669545 | http://purl.uniprot.org/core/title | "Retrograde Synaptic Inhibition Is Mediated by alpha-Neurexin Binding to the alpha2delta Subunits of N-Type Calcium Channels."xsd:string |
| http://purl.uniprot.org/citations/28669545 | http://purl.uniprot.org/core/volume | "95"xsd:string |
| http://purl.uniprot.org/citations/28669545 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28669545 |
| http://purl.uniprot.org/citations/28669545 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28669545 |
| http://purl.uniprot.org/uniprot/#_A0A0K3AVG1-mappedCitation-28669545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28669545 |
| http://purl.uniprot.org/uniprot/#_A0A0K3AVK6-mappedCitation-28669545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28669545 |
| http://purl.uniprot.org/uniprot/#_A0A0D9SEM5-mappedCitation-28669545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28669545 |
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| http://purl.uniprot.org/uniprot/#_A0A0K3AT61-mappedCitation-28669545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28669545 |
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| http://purl.uniprot.org/uniprot/#_A0A1D5RMU6-mappedCitation-28669545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28669545 |