| http://purl.uniprot.org/citations/28671665 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28671665 | http://www.w3.org/2000/01/rdf-schema#comment | "Aggregated forms of α-synuclein play a crucial role in the pathogenesis of synucleinopathies such as Parkinson's disease (PD). However, the molecular mechanisms underlying the pathogenic effects of α-synuclein are not completely understood. Here we show that asparagine endopeptidase (AEP) cleaves human α-synuclein, triggers its aggregation and escalates its neurotoxicity, thus leading to dopaminergic neuronal loss and motor impairments in a mouse model. AEP is activated and cleaves human α-synuclein at N103 in an age-dependent manner. AEP is highly activated in human brains with PD, and it fragments α-synuclein, which is found aggregated in Lewy bodies. Overexpression of the AEP-cleaved α-synuclein1-103 fragment in the substantia nigra induces both dopaminergic neuronal loss and movement defects in mice. In contrast, inhibition of AEP-mediated cleavage of α-synuclein (wild type and A53T mutant) diminishes α-synuclein's pathologic effects. Together, these findings support AEP's role as a key mediator of α-synuclein-related etiopathological effects in PD."xsd:string |
| http://purl.uniprot.org/citations/28671665 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.3433"xsd:string |
| http://purl.uniprot.org/citations/28671665 | http://purl.uniprot.org/core/author | "Jin L."xsd:string |
| http://purl.uniprot.org/citations/28671665 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/28671665 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/28671665 | http://purl.uniprot.org/core/author | "Zhang Z.'"xsd:string |
| http://purl.uniprot.org/citations/28671665 | http://purl.uniprot.org/core/author | "Ye K."xsd:string |
| http://purl.uniprot.org/citations/28671665 | http://purl.uniprot.org/core/author | "He L."xsd:string |
| http://purl.uniprot.org/citations/28671665 | http://purl.uniprot.org/core/author | "Iuvone P.M."xsd:string |
| http://purl.uniprot.org/citations/28671665 | http://purl.uniprot.org/core/author | "Kang S.S."xsd:string |
| http://purl.uniprot.org/citations/28671665 | http://purl.uniprot.org/core/author | "Wang J.Z."xsd:string |
| http://purl.uniprot.org/citations/28671665 | http://purl.uniprot.org/core/author | "Sun Y.E."xsd:string |
| http://purl.uniprot.org/citations/28671665 | http://purl.uniprot.org/core/author | "Seyfried N.T."xsd:string |
| http://purl.uniprot.org/citations/28671665 | http://purl.uniprot.org/core/author | "Duong D.M."xsd:string |
| http://purl.uniprot.org/citations/28671665 | http://purl.uniprot.org/core/author | "Ahn E.H."xsd:string |
| http://purl.uniprot.org/citations/28671665 | http://purl.uniprot.org/core/author | "Manfredsson F.P."xsd:string |
| http://purl.uniprot.org/citations/28671665 | http://purl.uniprot.org/core/author | "Benskey M.J."xsd:string |
| http://purl.uniprot.org/citations/28671665 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28671665 | http://purl.uniprot.org/core/name | "Nat Struct Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/28671665 | http://purl.uniprot.org/core/pages | "632-642"xsd:string |
| http://purl.uniprot.org/citations/28671665 | http://purl.uniprot.org/core/title | "Asparagine endopeptidase cleaves alpha-synuclein and mediates pathologic activities in Parkinson's disease."xsd:string |
| http://purl.uniprot.org/citations/28671665 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/28671665 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28671665 |
| http://purl.uniprot.org/citations/28671665 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28671665 |