| http://purl.uniprot.org/citations/28673385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28673385 | http://www.w3.org/2000/01/rdf-schema#comment | "Exophilin-8 has been reported to play a role in anchoring secretory granules within the actin cortex, due to its direct binding activities to Rab27 on the granule membrane and to F-actin and its motor protein, myosin-Va. Here, we show that exophilin-8 accumulates granules in the cortical F-actin network not by direct interaction with myosin-Va, but by indirect interaction with a specific form of myosin-VIIa through its previously unknown binding partner, RIM-BP2. RIM-BP2 also associates with exocytic machinery, Cav1.3, RIM, and Munc13-1. Disruption of the exophilin-8-RIM-BP2-myosin-VIIa complex by ablation or knockdown of each component markedly decreases both the peripheral accumulation and exocytosis of granules. Furthermore, exophilin-8-null mouse pancreatic islets lose polarized granule localization at the β-cell periphery and exhibit impaired insulin secretion. This newly identified complex acts as a physical and functional scaffold and provides a mechanism supporting a releasable pool of granules within the F-actin network beneath the plasma membrane."xsd:string |
| http://purl.uniprot.org/citations/28673385 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.26174"xsd:string |
| http://purl.uniprot.org/citations/28673385 | http://purl.uniprot.org/core/author | "Izumi T."xsd:string |
| http://purl.uniprot.org/citations/28673385 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/28673385 | http://purl.uniprot.org/core/author | "Kobayashi E."xsd:string |
| http://purl.uniprot.org/citations/28673385 | http://purl.uniprot.org/core/author | "Matsunaga K."xsd:string |
| http://purl.uniprot.org/citations/28673385 | http://purl.uniprot.org/core/author | "Fan F."xsd:string |
| http://purl.uniprot.org/citations/28673385 | http://purl.uniprot.org/core/author | "Kiyonari H."xsd:string |
| http://purl.uniprot.org/citations/28673385 | http://purl.uniprot.org/core/author | "Ishizaki R."xsd:string |
| http://purl.uniprot.org/citations/28673385 | http://purl.uniprot.org/core/author | "Mukumoto Y."xsd:string |
| http://purl.uniprot.org/citations/28673385 | http://purl.uniprot.org/core/author | "Okunishi K."xsd:string |
| http://purl.uniprot.org/citations/28673385 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28673385 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/28673385 | http://purl.uniprot.org/core/pages | "e26174"xsd:string |
| http://purl.uniprot.org/citations/28673385 | http://purl.uniprot.org/core/title | "Exophilin-8 assembles secretory granules for exocytosis in the actin cortex via interaction with RIM-BP2 and myosin-VIIa."xsd:string |
| http://purl.uniprot.org/citations/28673385 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/28673385 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28673385 |
| http://purl.uniprot.org/citations/28673385 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28673385 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J113-mappedCitation-28673385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28673385 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SQQ9-mappedCitation-28673385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28673385 |
| http://purl.uniprot.org/uniprot/#_A0A571BE72-mappedCitation-28673385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28673385 |
| http://purl.uniprot.org/uniprot/#_A0A571BEN3-mappedCitation-28673385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28673385 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RPT3-mappedCitation-28673385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28673385 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RPX7-mappedCitation-28673385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28673385 |