| http://purl.uniprot.org/citations/28676141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28676141 | http://www.w3.org/2000/01/rdf-schema#comment | "Environmental and genetic factors seem to play a pathogenetic role in multiple sclerosis (MS). The genetic component is partly suggested by familial aggregation of cases; however, MS families with affected subjects over different generations have rarely been described. The aim of this study was to report clinical and genetic features of a multigenerational MS family and to perform a review of the literature on this topic. We describe a multigenerational Italian family with six individuals affected by MS, showing different clinical and neuroradiological findings. HLA-DRB1* typing revealed the presence of the DRB1*15:01 allele in all the MS cases and in 4/5 non-affected subjects. Reports on six multigenerational MS families have previously been published, giving similar results. The HLA-DRB1*15:01 allele was confirmed to be linked to MS disease in this family; moreover, its presence in non-affected subjects suggests the involvement of other susceptibility factors in the development and expression of the disease, in accordance with the complex disease model now attributed to MS."xsd:string |
| http://purl.uniprot.org/citations/28676141 | http://purl.org/dc/terms/identifier | "doi:10.11138/fneur/2017.32.2.083"xsd:string |
| http://purl.uniprot.org/citations/28676141 | http://purl.uniprot.org/core/author | "Mosca L."xsd:string |
| http://purl.uniprot.org/citations/28676141 | http://purl.uniprot.org/core/author | "Penco S."xsd:string |
| http://purl.uniprot.org/citations/28676141 | http://purl.uniprot.org/core/author | "Agostoni E."xsd:string |
| http://purl.uniprot.org/citations/28676141 | http://purl.uniprot.org/core/author | "Grassi L."xsd:string |
| http://purl.uniprot.org/citations/28676141 | http://purl.uniprot.org/core/author | "Lando G."xsd:string |
| http://purl.uniprot.org/citations/28676141 | http://purl.uniprot.org/core/author | "De Benedetti S."xsd:string |
| http://purl.uniprot.org/citations/28676141 | http://purl.uniprot.org/core/author | "Mantero V."xsd:string |
| http://purl.uniprot.org/citations/28676141 | http://purl.uniprot.org/core/author | "Protti A."xsd:string |
| http://purl.uniprot.org/citations/28676141 | http://purl.uniprot.org/core/author | "Erminio C."xsd:string |
| http://purl.uniprot.org/citations/28676141 | http://purl.uniprot.org/core/author | "La Mantia L."xsd:string |
| http://purl.uniprot.org/citations/28676141 | http://purl.uniprot.org/core/author | "Marazzi M.R."xsd:string |
| http://purl.uniprot.org/citations/28676141 | http://purl.uniprot.org/core/author | "Spreafico C."xsd:string |
| http://purl.uniprot.org/citations/28676141 | http://purl.uniprot.org/core/author | "Zagaria M."xsd:string |
| http://purl.uniprot.org/citations/28676141 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28676141 | http://purl.uniprot.org/core/name | "Funct Neurol"xsd:string |
| http://purl.uniprot.org/citations/28676141 | http://purl.uniprot.org/core/pages | "83-88"xsd:string |
| http://purl.uniprot.org/citations/28676141 | http://purl.uniprot.org/core/title | "HLA-DRB1*15 association with multiple sclerosis is confirmed in a multigenerational Italian family."xsd:string |
| http://purl.uniprot.org/citations/28676141 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/28676141 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28676141 |
| http://purl.uniprot.org/citations/28676141 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28676141 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-28676141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28676141 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-28676141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28676141 |