| http://purl.uniprot.org/citations/28681593 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28681593 | http://www.w3.org/2000/01/rdf-schema#comment | "The 5-HT6R has been considered as an attractive therapeutic target in the brain due to its exclusive expression in the brain. However, the mechanistic linkage between 5-HT6Rs and brain functions remains poorly understood. Here, we examined the effects of 5-HT6R-mediated cell morphological changes using immunocytochemistry, Western blot, and live-cell imaging assays. Our results showed that the activation of 5-HT6Rs caused morphological changes and increased cell surface area in HEK293 cells expressing 5-HT6Rs. Treatment with 5-HT specifically increased RhoA-GTP activity without affecting other Rho family proteins, such as Rac1 and Cdc42. Furthermore, live-cell imaging in hippocampal neurons revealed that activation of 5-HT6Rs using a selective agonist, ST1936, increased the density and size of dendritic protrusions along with the activation of RhoA-GTP activity and that both effects were blocked by pretreatment with a selective 5-HT6R antagonist, SB258585. Taken together, our results show that 5-HT6R plays an important role in the regulation of cell morphology via a RhoA-dependent pathway in mammalian cell lines and primary neurons."xsd:string |
| http://purl.uniprot.org/citations/28681593 | http://purl.org/dc/terms/identifier | "doi:10.14348/molcells.2017.0080"xsd:string |
| http://purl.uniprot.org/citations/28681593 | http://purl.uniprot.org/core/author | "Kim Y."xsd:string |
| http://purl.uniprot.org/citations/28681593 | http://purl.uniprot.org/core/author | "Kim H."xsd:string |
| http://purl.uniprot.org/citations/28681593 | http://purl.uniprot.org/core/author | "Lee K.H."xsd:string |
| http://purl.uniprot.org/citations/28681593 | http://purl.uniprot.org/core/author | "Park M."xsd:string |
| http://purl.uniprot.org/citations/28681593 | http://purl.uniprot.org/core/author | "Rahman M.A."xsd:string |
| http://purl.uniprot.org/citations/28681593 | http://purl.uniprot.org/core/author | "Hong J.H."xsd:string |
| http://purl.uniprot.org/citations/28681593 | http://purl.uniprot.org/core/author | "Rhim H."xsd:string |
| http://purl.uniprot.org/citations/28681593 | http://purl.uniprot.org/core/author | "Yun H.M."xsd:string |
| http://purl.uniprot.org/citations/28681593 | http://purl.uniprot.org/core/author | "Choo H."xsd:string |
| http://purl.uniprot.org/citations/28681593 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28681593 | http://purl.uniprot.org/core/name | "Mol Cells"xsd:string |
| http://purl.uniprot.org/citations/28681593 | http://purl.uniprot.org/core/pages | "495-502"xsd:string |
| http://purl.uniprot.org/citations/28681593 | http://purl.uniprot.org/core/title | "5-Hydroxytryptamine 6 Receptor (5-HT6R)-Mediated Morphological Changes via RhoA-Dependent Pathways."xsd:string |
| http://purl.uniprot.org/citations/28681593 | http://purl.uniprot.org/core/volume | "40"xsd:string |
| http://purl.uniprot.org/citations/28681593 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28681593 |
| http://purl.uniprot.org/citations/28681593 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28681593 |
| http://purl.uniprot.org/uniprot/#_A0A8L2QXZ5-mappedCitation-28681593 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28681593 |
| http://purl.uniprot.org/uniprot/#_A6ITK1-mappedCitation-28681593 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28681593 |
| http://purl.uniprot.org/uniprot/#_P31388-mappedCitation-28681593 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28681593 |
| http://purl.uniprot.org/uniprot/#_Q63004-mappedCitation-28681593 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28681593 |
| http://purl.uniprot.org/uniprot/A0A8L2QXZ5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28681593 |
| http://purl.uniprot.org/uniprot/A6ITK1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28681593 |