Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/28682920http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/28682920http://www.w3.org/2000/01/rdf-schema#comment"

Introduction

Early diagnosis of acute kidney injury (AKI) remains a challenge. Recently, [TIMP-2]·[IGFBP7], which is a combination of urine tissue inhibitor of metalloproteinase 2 (TIMP-2) and insulin-like growth factor (IGF) binding protein 7 (IGFBP7), has been identified as a potential biomarker of AKI. We performed this meta-analysis to assess the diagnostic accuracy of urinary [TIMP-2]·[IGFBP7] for AKI in adult patients.

Methods

We searched the PubMed, Embase, and Cochrane Library databases from database inception to March 2017. Two authors independently screened articles based on inclusion and exclusion criteria and assessed the methodological quality of each included study using the Quality Assessment of Diagnostic Accuracy Studies 2 criteria. Review Manager and STATA were used for all statistical analyses.

Results

Nine studies (n = 1886) satisfied the inclusion criteria. Pooled analyses demonstrated that urinary [TIMP-2]·[IGFBP7] exhibited fair diagnostic accuracy for AKI (sensitivity [SEN] 0.83 [95% CI 0.75-0.89], specificity [SPE] 0.72 [95% CI 0.56-0.84], and area under the summary receiver operating characteristic [SROC] curve 0.86 [95% CI 0.82-0.88]) and AKI stage ≥ 2 (according to the 2012 Kidney Disease: Improving Global Outcomes [KDIGO] 2012 classification system; SEN 0.92 [95% CI 0.81-0.96], SPE 0.63 [95% CI 0.49-0.74], and area under the SROC curve 0.88 [95% CI 0.85-0.91]) in adult patients.

Conclusion

Our findings indicate that urinary [TIMP-2]·[IGFBP7] may be a reliable biomarker for the early detection of AKI. However, given the significant heterogeneity among the included studies, clinicians should be aware of the utility and limitations of this biomarker in clinical practice. Additional high-quality studies examining a larger sample of patients are required."xsd:string
http://purl.uniprot.org/citations/28682920http://purl.org/dc/terms/identifier"doi:10.1097/md.0000000000007484"xsd:string
http://purl.uniprot.org/citations/28682920http://purl.uniprot.org/core/author"Kang H."xsd:string
http://purl.uniprot.org/citations/28682920http://purl.uniprot.org/core/author"Liu H."xsd:string
http://purl.uniprot.org/citations/28682920http://purl.uniprot.org/core/author"Liu C."xsd:string
http://purl.uniprot.org/citations/28682920http://purl.uniprot.org/core/author"Lu X."xsd:string
http://purl.uniprot.org/citations/28682920http://purl.uniprot.org/core/author"Hu J."xsd:string
http://purl.uniprot.org/citations/28682920http://purl.uniprot.org/core/author"Pan L."xsd:string
http://purl.uniprot.org/citations/28682920http://purl.uniprot.org/core/author"Wang L."xsd:string
http://purl.uniprot.org/citations/28682920http://purl.uniprot.org/core/author"Zhou F."xsd:string
http://purl.uniprot.org/citations/28682920http://purl.uniprot.org/core/author"Mao Z."xsd:string
http://purl.uniprot.org/citations/28682920http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/28682920http://purl.uniprot.org/core/name"Medicine (Baltimore)"xsd:string
http://purl.uniprot.org/citations/28682920http://purl.uniprot.org/core/pages"e7484"xsd:string
http://purl.uniprot.org/citations/28682920http://purl.uniprot.org/core/title"The diagnostic accuracy of urinary [TIMP-2].[IGFBP7] for acute kidney injury in adults: A PRISMA-compliant meta-analysis."xsd:string
http://purl.uniprot.org/citations/28682920http://purl.uniprot.org/core/volume"96"xsd:string
http://purl.uniprot.org/citations/28682920http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/28682920
http://purl.uniprot.org/citations/28682920http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/28682920
http://purl.uniprot.org/uniprot/#_A0A140VK57-mappedCitation-28682920http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28682920
http://purl.uniprot.org/uniprot/#_B4DFW2-mappedCitation-28682920http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28682920
http://purl.uniprot.org/uniprot/#_Q16270-mappedCitation-28682920http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28682920
http://purl.uniprot.org/uniprot/#_P16035-mappedCitation-28682920http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/28682920
http://purl.uniprot.org/uniprot/Q16270http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/28682920
http://purl.uniprot.org/uniprot/B4DFW2http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/28682920
▶