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| http://purl.uniprot.org/citations/28687666 | http://www.w3.org/2000/01/rdf-schema#comment | "The migration of primordial germ cells (PGCs) from their place of origin to the embryonic gonad is an essential reproductive feature in many animal species. In Drosophila melanogaster, a single G protein-coupled receptor, Trapped in endoderm 1 (Tre1), mediates germ cell polarization at the onset of active migration and directs subsequent migration of PGCs through the midgut primordium. How these different aspects of cell behavior are coordinated through a single receptor is not known. We demonstrate that two highly conserved domains, the E/N/DRY and NPxxY motifs, have overlapping and unique functions in Tre1. The Tre1-NRY domain via G protein signaling is required for reading and responding to guidance and survival cues controlled by the lipid phosphate phosphatases Wunen and Wunen2. In contrast, the Tre1-NPIIY domain has a separate role in Rho1- and E-cadherin-mediated polarization at the initiation stage independent of G protein signaling. We propose that this bifurcation of the Tre1 G protein-coupled receptor signaling response via G protein-dependent and independent branches enables distinct spatiotemporal regulation of germ cell migration."xsd:string |
| http://purl.uniprot.org/citations/28687666 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201612053"xsd:string |
| http://purl.uniprot.org/citations/28687666 | http://purl.uniprot.org/core/author | "Lehmann R."xsd:string |
| http://purl.uniprot.org/citations/28687666 | http://purl.uniprot.org/core/author | "LeBlanc M.G."xsd:string |
| http://purl.uniprot.org/citations/28687666 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28687666 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/28687666 | http://purl.uniprot.org/core/pages | "2945-2958"xsd:string |
| http://purl.uniprot.org/citations/28687666 | http://purl.uniprot.org/core/title | "Domain-specific control of germ cell polarity and migration by multifunction Tre1 GPCR."xsd:string |
| http://purl.uniprot.org/citations/28687666 | http://purl.uniprot.org/core/volume | "216"xsd:string |
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