| http://purl.uniprot.org/citations/28691801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28691801 | http://www.w3.org/2000/01/rdf-schema#comment | "The second extracellular loop (ECL2) of the G protein-coupled receptor (GPCR) family is important for ligand interaction and drug discovery. ECL2 of the family B cardioprotective calcitonin gene-related peptide (CGRP) receptor is required for cell signaling. Family B GPCR ligands have two regions; the N-terminus mediates receptor activation, and the remainder confers high-affinity binding. Comparing antagonism of CGRP8-37 at a number of point mutations of ECL2 of the CGRP receptor, we show that the ECL2 potentially facilitates interaction with up to the 18 N-terminal residues of CGRP. This has implications for understanding family B GPCR activation and for drug design at the CGRP receptor."xsd:string |
| http://purl.uniprot.org/citations/28691801 | http://purl.org/dc/terms/identifier | "doi:10.1021/acs.biochem.7b00077"xsd:string |
| http://purl.uniprot.org/citations/28691801 | http://purl.uniprot.org/core/author | "Conner A.C."xsd:string |
| http://purl.uniprot.org/citations/28691801 | http://purl.uniprot.org/core/author | "Poyner D.R."xsd:string |
| http://purl.uniprot.org/citations/28691801 | http://purl.uniprot.org/core/author | "Simms J."xsd:string |
| http://purl.uniprot.org/citations/28691801 | http://purl.uniprot.org/core/author | "Uddin S."xsd:string |
| http://purl.uniprot.org/citations/28691801 | http://purl.uniprot.org/core/author | "Woolley M.J."xsd:string |
| http://purl.uniprot.org/citations/28691801 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28691801 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/28691801 | http://purl.uniprot.org/core/pages | "3877-3880"xsd:string |
| http://purl.uniprot.org/citations/28691801 | http://purl.uniprot.org/core/title | "Relative Antagonism of Mutants of the CGRP Receptor Extracellular Loop 2 Domain (ECL2) Using a Truncated Competitive Antagonist (CGRP8-37): Evidence for the Dual Involvement of ECL2 in the Two-Domain Binding Model."xsd:string |
| http://purl.uniprot.org/citations/28691801 | http://purl.uniprot.org/core/volume | "56"xsd:string |
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