| http://purl.uniprot.org/citations/28694260 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28694260 | http://www.w3.org/2000/01/rdf-schema#comment | "Distinct cortical interneuron (CIN) subtypes have unique circuit functions; dysfunction in specific subtypes is implicated in neuropsychiatric disorders. Somatostatin- and parvalbumin-expressing (SST+ and PV+) interneurons are the two major subtypes generated by medial ganglionic eminence (MGE) progenitors. Spatial and temporal mechanisms governing their cell-fate specification and differential integration into cortical layers are largely unknown. We provide evidence that Coup-TF1 and Coup-TF2 (Nr2f1 and Nr2f2) transcription factor expression in an arc-shaped progenitor domain within the MGE promotes time-dependent survival of this neuroepithelium and the time-dependent specification of layer V SST+ CINs. Coup-TF1 and Coup-TF2 autonomously repress PV+ fate in MGE progenitors, in part through directly driving Sox6 expression. These results have identified, in mouse, a transcriptional pathway that controls SST-PV fate."xsd:string |
| http://purl.uniprot.org/citations/28694260 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.150664"xsd:string |
| http://purl.uniprot.org/citations/28694260 | http://purl.uniprot.org/core/author | "Hu J.S."xsd:string |
| http://purl.uniprot.org/citations/28694260 | http://purl.uniprot.org/core/author | "Sandberg M."xsd:string |
| http://purl.uniprot.org/citations/28694260 | http://purl.uniprot.org/core/author | "Rubenstein J.L.R."xsd:string |
| http://purl.uniprot.org/citations/28694260 | http://purl.uniprot.org/core/author | "Lindtner S."xsd:string |
| http://purl.uniprot.org/citations/28694260 | http://purl.uniprot.org/core/author | "Vogt D."xsd:string |
| http://purl.uniprot.org/citations/28694260 | http://purl.uniprot.org/core/author | "Silberberg S.N."xsd:string |
| http://purl.uniprot.org/citations/28694260 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28694260 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/28694260 | http://purl.uniprot.org/core/pages | "2837-2851"xsd:string |
| http://purl.uniprot.org/citations/28694260 | http://purl.uniprot.org/core/title | "Coup-TF1 and Coup-TF2 control subtype and laminar identity of MGE-derived neocortical interneurons."xsd:string |
| http://purl.uniprot.org/citations/28694260 | http://purl.uniprot.org/core/volume | "144"xsd:string |
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