| http://purl.uniprot.org/citations/28694430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28694430 | http://www.w3.org/2000/01/rdf-schema#comment | "Map3k8 has been proposed as a useful target for the treatment of inflammatory diseases. We show here that during lipopolysaccharide-induced emergency granulopoiesis, Map3k8 deficiency strongly impairs the increase in circulating mature (Ly6GhighCD11b+) and immature (Ly6GlowCD11b+) neutrophils. After chimaeric bone marrow (BM) transplantation into recipient Map3k8-/- mice, lipopolysaccharide treatment did not increase circulating Ly6GhighCD11b+ cells and strongly decreased circulating Ly6GlowCD11b+ cells. Lipopolysaccharide-treated Map3k8-/- mice showed decreased production of granulocyte colony-stimulating factor (G-CSF), a key factor in neutrophil expansion, and a Map3k8 inhibitor blocked lipopolysaccharide-mediated G-CSF expression in endothelial cell lines. Ly6GlowCD11b+ BM cells from lipopolysaccharide-treated Map3k8-/- mice displayed impaired expression of CCAAT-enhancer-binding protein β, which depends on G-CSF for expression and is crucial for cell cycle acceleration in this life-threatening condition. Accordingly, lipopolysaccharide-treated Map3k8-/- mice showed decreased Ly6GlowCD11b+ BM cell proliferation, as evidenced by a decrease in the percentage of the most immature precursors, which have the highest proliferation capacity among this cell population. Thus, Map3k8 expression by non-haematopoietic tissue is required for lipopolysaccharide-induced emergency granulopoiesis. The novel observation that inhibition of Map3k8 activity decreases neutrophilia during life-threatening systemic infection suggests a possible risk in the proposed use of Map3k8 blockade as an anti-inflammatory therapy."xsd:string |
| http://purl.uniprot.org/citations/28694430 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-017-04538-3"xsd:string |
| http://purl.uniprot.org/citations/28694430 | http://purl.uniprot.org/core/author | "Sanchez A."xsd:string |
| http://purl.uniprot.org/citations/28694430 | http://purl.uniprot.org/core/author | "Carrasco A."xsd:string |
| http://purl.uniprot.org/citations/28694430 | http://purl.uniprot.org/core/author | "Aranda A."xsd:string |
| http://purl.uniprot.org/citations/28694430 | http://purl.uniprot.org/core/author | "Alemany S."xsd:string |
| http://purl.uniprot.org/citations/28694430 | http://purl.uniprot.org/core/author | "Martin-Duce A."xsd:string |
| http://purl.uniprot.org/citations/28694430 | http://purl.uniprot.org/core/author | "Contreras-Jurado C."xsd:string |
| http://purl.uniprot.org/citations/28694430 | http://purl.uniprot.org/core/author | "Relano C."xsd:string |
| http://purl.uniprot.org/citations/28694430 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28694430 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/28694430 | http://purl.uniprot.org/core/pages | "5010"xsd:string |
| http://purl.uniprot.org/citations/28694430 | http://purl.uniprot.org/core/title | "Map3k8 controls granulocyte colony-stimulating factor production and neutrophil precursor proliferation in lipopolysaccharide-induced emergency granulopoiesis."xsd:string |
| http://purl.uniprot.org/citations/28694430 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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