| http://purl.uniprot.org/citations/28698313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28698313 | http://www.w3.org/2000/01/rdf-schema#comment | "Monocyte-derived Mϕs (MDMs) from HIV-infected patients and MDM infected in vitro with HIV exhibit a reduced ability to secrete various cytokines, including IL-12. Recently, IL-27, an IL-12 family cytokine, was shown to inhibit HIV replication in Mϕ. Whether HIV infection or HIV accessory protein(s) impact IL-27 production in Mϕs remains unknown. Herein, we show that in vitro HIV infection, as well as intracellular HIV-Tat (Tat) and Tat peptides, inhibit LPS-induced IL-27 production in human MDMs, suggesting impairment of the TLR4 signaling pathway. To understand the signaling pathways governing HIV or Tat-mediated inhibition of LPS-induced IL-27 production, we first demonstrated that p38 MAPK, PI3K, Src-homology region 2 domain-containing tyrosine phosphatase 1 (SHP-1), and Src kinases regulate LPS-induced IL-27 production in MDMs. Tat caused down-regulation of TNFR-associated factor (TRAF)-6 and inhibitor of apoptosis 1 (cIAP-1) and subsequently decreased phosphorylation of downstream PI3K and p38 MAPKs, which were implicated in LPS-induced IL-27 production. Whereas SHP-1 and Src kinases regulated LPS-induced IL-27 production, Tat did not inhibit these kinases, suggesting that they were not involved in Tat-mediated inhibition of LPS-induced IL-27 production. In contrast to Tat, in vitro HIV infection of MDM inhibited LPS-induced IL-27 production via inhibition of p38 MAPK activation. Overall, HIV and Tat inhibit LPS-induced IL-27 production in human macrophages via distinct mechanisms: Tat through the inhibition of cIAP-1-TRAF-6 and subsequent inhibition of PI3K and p38 MAPKs, whereas HIV through the inhibition of p38 MAPK activation."xsd:string |
| http://purl.uniprot.org/citations/28698313 | http://purl.org/dc/terms/identifier | "doi:10.1189/jlb.4a0716-332rr"xsd:string |
| http://purl.uniprot.org/citations/28698313 | http://purl.uniprot.org/core/author | "Fernandes J."xsd:string |
| http://purl.uniprot.org/citations/28698313 | http://purl.uniprot.org/core/author | "Kumar A."xsd:string |
| http://purl.uniprot.org/citations/28698313 | http://purl.uniprot.org/core/author | "O'Hara S."xsd:string |
| http://purl.uniprot.org/citations/28698313 | http://purl.uniprot.org/core/author | "Angel J.B."xsd:string |
| http://purl.uniprot.org/citations/28698313 | http://purl.uniprot.org/core/author | "Gajanayaka N."xsd:string |
| http://purl.uniprot.org/citations/28698313 | http://purl.uniprot.org/core/author | "Kozlowski M."xsd:string |
| http://purl.uniprot.org/citations/28698313 | http://purl.uniprot.org/core/author | "Muthumani K."xsd:string |
| http://purl.uniprot.org/citations/28698313 | http://purl.uniprot.org/core/author | "Konarski Y."xsd:string |
| http://purl.uniprot.org/citations/28698313 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28698313 | http://purl.uniprot.org/core/name | "J Leukoc Biol"xsd:string |
| http://purl.uniprot.org/citations/28698313 | http://purl.uniprot.org/core/pages | "925-939"xsd:string |
| http://purl.uniprot.org/citations/28698313 | http://purl.uniprot.org/core/title | "HIV and HIV-Tat inhibit LPS-induced IL-27 production in human macrophages by distinct intracellular signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/28698313 | http://purl.uniprot.org/core/volume | "102"xsd:string |
| http://purl.uniprot.org/citations/28698313 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28698313 |
| http://purl.uniprot.org/citations/28698313 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28698313 |
| http://purl.uniprot.org/uniprot/#_P04608-mappedCitation-28698313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28698313 |
| http://purl.uniprot.org/uniprot/#_Q8NEV9-mappedCitation-28698313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28698313 |
| http://purl.uniprot.org/uniprot/Q8NEV9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28698313 |
| http://purl.uniprot.org/uniprot/P04608 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28698313 |