| http://purl.uniprot.org/citations/28698383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28698383 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytokine-induced endoplasmic reticulum (ER) stress is one of the molecular mechanisms underlying pancreatic β-cell demise in type 1 diabetes. Thrombospondin 1 (THBS1) was recently shown to promote β-cell survival during lipotoxic stress. Here we show that ER-localized THBS1 is cytoprotective to rat, mouse, and human β-cells exposed to cytokines or thapsigargin-induced ER stress. THBS1 confers cytoprotection by maintaining expression of mesencephalic astrocyte-derived neutrotrophic factor (MANF) in β-cells and thereby prevents the BH3-only protein BIM (BCL2-interacting mediator of cell death)-dependent triggering of the mitochondrial pathway of apoptosis. Prolonged exposure of β-cells to cytokines or thapsigargin leads to THBS1 and MANF degradation and loss of this prosurvival mechanism. Approaches that sustain intracellular THBS1 and MANF expression in β-cells should be explored as a cytoprotective strategy in type 1 diabetes."xsd:string |
| http://purl.uniprot.org/citations/28698383 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m116.769877"xsd:string |
| http://purl.uniprot.org/citations/28698383 | http://purl.uniprot.org/core/author | "Cunha D.A."xsd:string |
| http://purl.uniprot.org/citations/28698383 | http://purl.uniprot.org/core/author | "Bugliani M."xsd:string |
| http://purl.uniprot.org/citations/28698383 | http://purl.uniprot.org/core/author | "Marchetti P."xsd:string |
| http://purl.uniprot.org/citations/28698383 | http://purl.uniprot.org/core/author | "Lindahl M."xsd:string |
| http://purl.uniprot.org/citations/28698383 | http://purl.uniprot.org/core/author | "Domanskyi A."xsd:string |
| http://purl.uniprot.org/citations/28698383 | http://purl.uniprot.org/core/author | "Cnop M."xsd:string |
| http://purl.uniprot.org/citations/28698383 | http://purl.uniprot.org/core/author | "Eizirik D.L."xsd:string |
| http://purl.uniprot.org/citations/28698383 | http://purl.uniprot.org/core/author | "Cosentino C."xsd:string |
| http://purl.uniprot.org/citations/28698383 | http://purl.uniprot.org/core/author | "Danilova T."xsd:string |
| http://purl.uniprot.org/citations/28698383 | http://purl.uniprot.org/core/author | "Ladriere L."xsd:string |
| http://purl.uniprot.org/citations/28698383 | http://purl.uniprot.org/core/author | "Grieco F.A."xsd:string |
| http://purl.uniprot.org/citations/28698383 | http://purl.uniprot.org/core/author | "Cito M."xsd:string |
| http://purl.uniprot.org/citations/28698383 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28698383 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/28698383 | http://purl.uniprot.org/core/pages | "14977-14988"xsd:string |
| http://purl.uniprot.org/citations/28698383 | http://purl.uniprot.org/core/title | "Pancreatic beta-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF)."xsd:string |
| http://purl.uniprot.org/citations/28698383 | http://purl.uniprot.org/core/volume | "292"xsd:string |
| http://purl.uniprot.org/citations/28698383 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28698383 |
| http://purl.uniprot.org/citations/28698383 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28698383 |
| http://purl.uniprot.org/uniprot/#_A8C1V1-mappedCitation-28698383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28698383 |
| http://purl.uniprot.org/uniprot/#_F7C1S6-mappedCitation-28698383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28698383 |
| http://purl.uniprot.org/uniprot/#_F6USD5-mappedCitation-28698383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28698383 |