| http://purl.uniprot.org/citations/28699853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28699853 | http://www.w3.org/2000/01/rdf-schema#comment | "The connection between the repression of human immunodeficiency virus type 1(HIV-1) transcription and the resting CD4+ T cell state suggests that the host transcription factors involved in the active maintenance of lymphocyte quiescence are likely to repress the viral transactivator, Tat, thereby restricting HIV-1 transcription. In this study, we analysed the interplay between Tat and the forkhead box transcription factors, FoxO1 and FoxO4. We show that FoxO1 and FoxO4 antagonize Tat-mediated transactivation of HIV-1 promoter through the repression of Tat protein expression. No effect was observed on the expression of two HIV-1 accessory proteins, Vif and Vpr. Unexpectedly, we found that FoxO1 and FoxO4 expression causes a strong dose-dependent post-transcriptional suppression of Tat mRNA, indicating that FoxO should effectively inhibit HIV-1 replication by destabilizing Tat mRNA and suppressing Tat-mediated HIV-1 transcription. In accordance with this, we observed that the Tat mRNA half-life is reduced by FoxO4 expression. The physiological relevance of our findings was validated using the J-Lat 10.6 model of latently infected cells. We demonstrated that the overexpression of a constitutively active FoxO4-TM mutant antagonized HIV-1 transcription reactivation in response to T cell activators, such as TNF-α or PMA. Altogether, our findings demonstrate that FoxO factors can control HIV-1 transcription and provide new insights into their potential role during the establishment of HIV-1 latency."xsd:string |
| http://purl.uniprot.org/citations/28699853 | http://purl.org/dc/terms/identifier | "doi:10.1099/jgv.0.000837"xsd:string |
| http://purl.uniprot.org/citations/28699853 | http://purl.uniprot.org/core/author | "Mechti N."xsd:string |
| http://purl.uniprot.org/citations/28699853 | http://purl.uniprot.org/core/author | "Oteiza A."xsd:string |
| http://purl.uniprot.org/citations/28699853 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28699853 | http://purl.uniprot.org/core/name | "J Gen Virol"xsd:string |
| http://purl.uniprot.org/citations/28699853 | http://purl.uniprot.org/core/pages | "1864-1878"xsd:string |
| http://purl.uniprot.org/citations/28699853 | http://purl.uniprot.org/core/title | "FoxO4 negatively controls Tat-mediated HIV-1 transcription through the post-transcriptional suppression of Tat encoding mRNA."xsd:string |
| http://purl.uniprot.org/citations/28699853 | http://purl.uniprot.org/core/volume | "98"xsd:string |
| http://purl.uniprot.org/citations/28699853 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28699853 |
| http://purl.uniprot.org/citations/28699853 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28699853 |
| http://purl.uniprot.org/uniprot/#_B4DTB6-mappedCitation-28699853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28699853 |
| http://purl.uniprot.org/uniprot/#_P04608-mappedCitation-28699853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28699853 |
| http://purl.uniprot.org/uniprot/#_P98177-mappedCitation-28699853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28699853 |
| http://purl.uniprot.org/uniprot/P98177 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28699853 |
| http://purl.uniprot.org/uniprot/P04608 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28699853 |
| http://purl.uniprot.org/uniprot/B4DTB6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28699853 |