| http://purl.uniprot.org/citations/28701359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28701359 | http://www.w3.org/2000/01/rdf-schema#comment | "Oxidized modifications of LDL (oxLDL) play a key role in the development of endothelial dysfunction and atherosclerosis. However, the underlying mechanisms of oxLDL-mediated cellular behavior are not completely understood. Here, we compared the effects of two major types of oxLDL, copper-oxidized LDL (Cu2+-oxLDL) and lipoxygenase-oxidized LDL (LPO-oxLDL), on proliferation of human aortic endothelial cells (HAECs). Cu2+-oxLDL enhanced HAECs' proliferation in a dose- and degree of oxidation-dependent manner. Similarly, LPO-oxLDL also enhanced HAEC proliferation. Mechanistically, both Cu2+-oxLDL and LPO-oxLDL enhance HAEC proliferation via activation of Rho, Akt phosphorylation, and a decrease in the expression of cyclin-dependent kinase inhibitor 1B (p27kip1). Both Cu2+-oxLDL or LPO-oxLDL significantly increased Akt phosphorylation, whereas an Akt inhibitor, MK2206, blocked oxLDL-induced increase in HAEC proliferation. Blocking Rho with C3 or its downstream target ROCK with Y27632 significantly inhibited oxLDL-induced Akt phosphorylation and proliferation mediated by both Cu2+- and LPO-oxLDL. Activation of RhoA was blocked by Rho-GDI-1, which also abrogated oxLDL-induced Akt phosphorylation and HAEC proliferation. In contrast, blocking Rac1 in these cells had no effect on oxLDL-induced Akt phosphorylation or cell proliferation. Moreover, oxLDL-induced Rho/Akt signaling downregulated cell cycle inhibitor p27kip1 Preloading these cells with cholesterol, however, prevented oxLDL-induced Akt phosphorylation and HAEC proliferation. These findings provide a new understanding of the effects of oxLDL on endothelial proliferation, which is essential for developing new treatments against neovascularization and progression of atherosclerosis."xsd:string |
| http://purl.uniprot.org/citations/28701359 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpcell.00249.2016"xsd:string |
| http://purl.uniprot.org/citations/28701359 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/28701359 | http://purl.uniprot.org/core/author | "Oh M.J."xsd:string |
| http://purl.uniprot.org/citations/28701359 | http://purl.uniprot.org/core/author | "Mehta D."xsd:string |
| http://purl.uniprot.org/citations/28701359 | http://purl.uniprot.org/core/author | "Wary K.K."xsd:string |
| http://purl.uniprot.org/citations/28701359 | http://purl.uniprot.org/core/author | "Levitan I."xsd:string |
| http://purl.uniprot.org/citations/28701359 | http://purl.uniprot.org/core/author | "Baruah J."xsd:string |
| http://purl.uniprot.org/citations/28701359 | http://purl.uniprot.org/core/author | "Adamos C."xsd:string |
| http://purl.uniprot.org/citations/28701359 | http://purl.uniprot.org/core/author | "Ayee M.A.A."xsd:string |
| http://purl.uniprot.org/citations/28701359 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28701359 | http://purl.uniprot.org/core/name | "Am J Physiol Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/28701359 | http://purl.uniprot.org/core/pages | "C340-C351"xsd:string |
| http://purl.uniprot.org/citations/28701359 | http://purl.uniprot.org/core/title | "oxLDL induces endothelial cell proliferation via Rho/ROCK/Akt/p27kip1 signaling: opposite effects of oxLDL and cholesterol loading."xsd:string |
| http://purl.uniprot.org/citations/28701359 | http://purl.uniprot.org/core/volume | "313"xsd:string |
| http://purl.uniprot.org/citations/28701359 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28701359 |
| http://purl.uniprot.org/citations/28701359 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28701359 |
| http://purl.uniprot.org/uniprot/#_A0A0K0Q0G7-mappedCitation-28701359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28701359 |
| http://purl.uniprot.org/uniprot/#_A0A076V826-mappedCitation-28701359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28701359 |
| http://purl.uniprot.org/uniprot/#_A0A0M3R835-mappedCitation-28701359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28701359 |
| http://purl.uniprot.org/uniprot/#_B3KVH4-mappedCitation-28701359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28701359 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3D6-mappedCitation-28701359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28701359 |
| http://purl.uniprot.org/uniprot/#_A0A142IKA9-mappedCitation-28701359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28701359 |
| http://purl.uniprot.org/uniprot/#_B0LPE5-mappedCitation-28701359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28701359 |