| http://purl.uniprot.org/citations/28704726 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28704726 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitophagy under hypoxia is an important factor for maintaining and regulating stem cell functions. We previously demonstrated that fatty acid synthase (FASN) induced by hypoxia is a critical lipid metabolic factor determining the therapeutic efficacy of umbilical cord blood-derived human mesenchymal stem cells (UCB-hMSCs). Therefore, we investigated the mechanism of a major mitophagy regulator controlling lipid metabolism and therapeutic potential of UCB-hMSCs. This study revealed that Bcl2/adenovirus E1B 19kDa protein-interacting protein 3 (BNIP3)-dependent mitophagy is important for reducing mitochondrial reactive oxygen species accumulation, anti-apoptosis, and migration under hypoxia. And, BNIP3 expression was regulated by CREB binding protein-mediated transcriptional actions of HIF-1α and FOXO3. Silencing of BNIP3 suppressed free fatty acid (FFA) synthesis regulated by SREBP1/FASN pathway, which is involved in UCB-hMSC apoptosis via caspases cleavage and migration via cofilin-1-mediated F-actin reorganization in hypoxia. Moreover, reduced mouse skin wound-healing capacity of UCB-hMSC with hypoxia pretreatment by BNIP3 silencing was recovered by palmitic acid. Collectively, our findings suggest that BNIP3-mediated mitophagy under hypoxia leads to FASN-induced FFA synthesis, which is critical for therapeutic potential of UCB-hMSCs with hypoxia pretreatment."xsd:string |
| http://purl.uniprot.org/citations/28704726 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.redox.2017.07.004"xsd:string |
| http://purl.uniprot.org/citations/28704726 | http://purl.uniprot.org/core/author | "Lee S.J."xsd:string |
| http://purl.uniprot.org/citations/28704726 | http://purl.uniprot.org/core/author | "Lee S.H."xsd:string |
| http://purl.uniprot.org/citations/28704726 | http://purl.uniprot.org/core/author | "Lee H.J."xsd:string |
| http://purl.uniprot.org/citations/28704726 | http://purl.uniprot.org/core/author | "Ko S.H."xsd:string |
| http://purl.uniprot.org/citations/28704726 | http://purl.uniprot.org/core/author | "Han H.J."xsd:string |
| http://purl.uniprot.org/citations/28704726 | http://purl.uniprot.org/core/author | "Jung Y.H."xsd:string |
| http://purl.uniprot.org/citations/28704726 | http://purl.uniprot.org/core/author | "Choi G.E."xsd:string |
| http://purl.uniprot.org/citations/28704726 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28704726 | http://purl.uniprot.org/core/name | "Redox Biol"xsd:string |
| http://purl.uniprot.org/citations/28704726 | http://purl.uniprot.org/core/pages | "426-443"xsd:string |
| http://purl.uniprot.org/citations/28704726 | http://purl.uniprot.org/core/title | "BNIP3 induction by hypoxia stimulates FASN-dependent free fatty acid production enhancing therapeutic potential of umbilical cord blood-derived human mesenchymal stem cells."xsd:string |
| http://purl.uniprot.org/citations/28704726 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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