| http://purl.uniprot.org/citations/28712654 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28712654 | http://www.w3.org/2000/01/rdf-schema#comment | "Activity-dependent neuronal plasticity is a fundamental mechanism through which the nervous system adapts to sensory experience. Several lines of evidence suggest that parvalbumin (PV+) interneurons are essential in this process, but the molecular mechanisms underlying the influence of experience on interneuron plasticity remain poorly understood. Perineuronal nets (PNNs) enwrapping PV+ cells are long-standing candidates for playing such a role, yet their precise contribution has remained elusive. We show that the PNN protein Brevican is a critical regulator of interneuron plasticity. We find that Brevican simultaneously controls cellular and synaptic forms of plasticity in PV+ cells by regulating the localization of potassium channels and AMPA receptors, respectively. By modulating Brevican levels, experience introduces precise molecular and cellular modifications in PV+ cells that are required for learning and memory. These findings uncover a molecular program through which a PNN protein facilitates appropriate behavioral responses to experience by dynamically gating PV+ interneuron function."xsd:string |
| http://purl.uniprot.org/citations/28712654 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2017.06.028"xsd:string |
| http://purl.uniprot.org/citations/28712654 | http://purl.uniprot.org/core/author | "Fernandes C."xsd:string |
| http://purl.uniprot.org/citations/28712654 | http://purl.uniprot.org/core/author | "Rico B."xsd:string |
| http://purl.uniprot.org/citations/28712654 | http://purl.uniprot.org/core/author | "Deogracias R."xsd:string |
| http://purl.uniprot.org/citations/28712654 | http://purl.uniprot.org/core/author | "Favuzzi E."xsd:string |
| http://purl.uniprot.org/citations/28712654 | http://purl.uniprot.org/core/author | "Maeso P."xsd:string |
| http://purl.uniprot.org/citations/28712654 | http://purl.uniprot.org/core/author | "Marques-Smith A."xsd:string |
| http://purl.uniprot.org/citations/28712654 | http://purl.uniprot.org/core/author | "Sanchez-Aguilera A."xsd:string |
| http://purl.uniprot.org/citations/28712654 | http://purl.uniprot.org/core/author | "Ewers H."xsd:string |
| http://purl.uniprot.org/citations/28712654 | http://purl.uniprot.org/core/author | "Winterflood C.M."xsd:string |
| http://purl.uniprot.org/citations/28712654 | http://purl.uniprot.org/core/author | "Mantoan L."xsd:string |
| http://purl.uniprot.org/citations/28712654 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28712654 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/28712654 | http://purl.uniprot.org/core/pages | "639-655.e10"xsd:string |
| http://purl.uniprot.org/citations/28712654 | http://purl.uniprot.org/core/title | "Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican."xsd:string |
| http://purl.uniprot.org/citations/28712654 | http://purl.uniprot.org/core/volume | "95"xsd:string |
| http://purl.uniprot.org/citations/28712654 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28712654 |
| http://purl.uniprot.org/citations/28712654 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28712654 |
| http://purl.uniprot.org/uniprot/Q61361#attribution-5530A159CB6096382BF5F659039E1162 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/28712654 |
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| http://purl.uniprot.org/uniprot/#_A0A0R4J003-mappedCitation-28712654 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28712654 |
| http://purl.uniprot.org/uniprot/#_E9PX01-mappedCitation-28712654 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28712654 |
| http://purl.uniprot.org/uniprot/#_C9K0Y7-mappedCitation-28712654 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28712654 |