| http://purl.uniprot.org/citations/28712808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28712808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28712808 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein kinases play central roles in the survival of Mycobacterium tuberculosis within host. Here we report the individual high-resolution crystal structures of the sensor domain (in both monomer and dimer forms) and the kinase domain of PknI, a transmembrane protein member of the serine/threonine protein kinases (STPKs) family. PknI is the first STPK identified whose sensor domain exists in a monomer-dimer equilibrium. Inspection of the two structures of the sensor domain (PknI_SD) revealed conformational changes upon dimerization, with an arm region of critical importance for dimer formation identified. Rapamycin-induced dimerization of unphosphorylated fusions of PknI juxtamembrane and the kinase domain, intended to mimic the dimerization effect presumably imposed by PknI_SD, was observed to be able to activate auto-phosphorylation activity of the kinase domain. In vivo experiments using an M. bovis model suggested PknI functions as a dimer in the regulation of M. tuberculosis growth."xsd:string |
| http://purl.uniprot.org/citations/28712808 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2017.06.010"xsd:string |
| http://purl.uniprot.org/citations/28712808 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2017.06.010"xsd:string |
| http://purl.uniprot.org/citations/28712808 | http://purl.uniprot.org/core/author | "Rao Z."xsd:string |
| http://purl.uniprot.org/citations/28712808 | http://purl.uniprot.org/core/author | "Rao Z."xsd:string |
| http://purl.uniprot.org/citations/28712808 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/28712808 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/28712808 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/28712808 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/28712808 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/28712808 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/28712808 | http://purl.uniprot.org/core/author | "Yan Q."xsd:string |
| http://purl.uniprot.org/citations/28712808 | http://purl.uniprot.org/core/author | "Yan Q."xsd:string |
| http://purl.uniprot.org/citations/28712808 | http://purl.uniprot.org/core/author | "Zhou W."xsd:string |
| http://purl.uniprot.org/citations/28712808 | http://purl.uniprot.org/core/author | "Zhou W."xsd:string |
| http://purl.uniprot.org/citations/28712808 | http://purl.uniprot.org/core/author | "Jiang D."xsd:string |
| http://purl.uniprot.org/citations/28712808 | http://purl.uniprot.org/core/author | "Jiang D."xsd:string |
| http://purl.uniprot.org/citations/28712808 | http://purl.uniprot.org/core/author | "Qian L."xsd:string |
| http://purl.uniprot.org/citations/28712808 | http://purl.uniprot.org/core/author | "Qian L."xsd:string |
| http://purl.uniprot.org/citations/28712808 | http://purl.uniprot.org/core/author | "Mi K."xsd:string |
| http://purl.uniprot.org/citations/28712808 | http://purl.uniprot.org/core/author | "Mi K."xsd:string |
| http://purl.uniprot.org/citations/28712808 | http://purl.uniprot.org/core/author | "Guddat L."xsd:string |
| http://purl.uniprot.org/citations/28712808 | http://purl.uniprot.org/core/author | "Guddat L."xsd:string |