| http://purl.uniprot.org/citations/28714470 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28714470 | http://www.w3.org/2000/01/rdf-schema#comment | "Hematopoietic stem cells (HSCs) are maintained in a hypoxic niche to limit oxidative stress. Although iron elicits oxidative stress, the importance of iron homeostasis in HSCs has been unknown. Here we show that iron regulation by the F-box protein FBXL5 is required for HSC self-renewal. Conditional deletion of Fbxl5 in mouse HSCs results in cellular iron overload and a reduced cell number. Bone marrow transplantation reveals that FBXL5-deficient HSCs are unable to reconstitute the hematopoietic system of irradiated recipients as a result of stem cell exhaustion. Transcriptomic analysis shows abnormal activation of oxidative stress responses and the cell cycle in FBXL5-deficient mouse HSCs as well as downregulation of FBXL5 expression in HSCs of patients with myelodysplastic syndrome. Suppression of iron regulatory protein 2 (IRP2) accumulation in FBXL5-deficient mouse HSCs restores stem cell function, implicating IRP2 as a potential therapeutic target for human hematopoietic diseases associated with FBXL5 downregulation."xsd:string |
| http://purl.uniprot.org/citations/28714470 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms16114"xsd:string |
| http://purl.uniprot.org/citations/28714470 | http://purl.uniprot.org/core/author | "Nishiyama M."xsd:string |
| http://purl.uniprot.org/citations/28714470 | http://purl.uniprot.org/core/author | "Muto Y."xsd:string |
| http://purl.uniprot.org/citations/28714470 | http://purl.uniprot.org/core/author | "Nakayama K.I."xsd:string |
| http://purl.uniprot.org/citations/28714470 | http://purl.uniprot.org/core/author | "Moroishi T."xsd:string |
| http://purl.uniprot.org/citations/28714470 | http://purl.uniprot.org/core/author | "Nita A."xsd:string |
| http://purl.uniprot.org/citations/28714470 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28714470 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/28714470 | http://purl.uniprot.org/core/pages | "16114"xsd:string |
| http://purl.uniprot.org/citations/28714470 | http://purl.uniprot.org/core/title | "Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells."xsd:string |
| http://purl.uniprot.org/citations/28714470 | http://purl.uniprot.org/core/volume | "8"xsd:string |
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