| http://purl.uniprot.org/citations/28716903 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28716903 | http://www.w3.org/2000/01/rdf-schema#comment | "The class III PI3K Vacuolar protein sorting 34 (Vps34) plays a role in both canonical and noncanonical autophagy, key processes that control the presentation of antigens by dendritic cells (DCs) to naive T lymphocytes. We generated DC-specific Vps34-deficient mice to assess the contribution of Vps34 to DC functions. We found that DCs from these animals have a partially activated phenotype, spontaneously produce cytokines, and exhibit enhanced activity of the classic MHC class I and class II antigen-presentation pathways. Surprisingly, these animals displayed a defect in the homeostatic maintenance of splenic CD8α+ DCs and in the capacity of these cells to cross-present cell corpse-associated antigens to MHC class I-restricted T cells, a property that was associated with defective expression of the T-cell Ig mucin (TIM)-4 receptor. Importantly, mice deficient in the Vps34-associated protein Rubicon, which is critical for a noncanonical form of autophagy called "Light-chain 3 (LC3)-associated phagocytosis" (LAP), lacked such defects. Finally, consistent with their defect in the cross-presentation of apoptotic cells, DC-specific Vps34-deficient animals developed increased metastases in response to challenge with B16 melanoma cells. Collectively, our studies have revealed a critical role of Vps34 in the regulation of CD8α+ DC homeostasis and in the capacity of these cells to process and present antigens associated with apoptotic cells to MHC class I-restricted T cells. Our findings also have important implications for the development of small-molecule inhibitors of Vps34 for therapeutic purposes."xsd:string |
| http://purl.uniprot.org/citations/28716903 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1706504114"xsd:string |
| http://purl.uniprot.org/citations/28716903 | http://purl.uniprot.org/core/author | "Martinez J."xsd:string |
| http://purl.uniprot.org/citations/28716903 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/28716903 | http://purl.uniprot.org/core/author | "Wu L."xsd:string |
| http://purl.uniprot.org/citations/28716903 | http://purl.uniprot.org/core/author | "Van Kaer L."xsd:string |
| http://purl.uniprot.org/citations/28716903 | http://purl.uniprot.org/core/author | "Sebzda E."xsd:string |
| http://purl.uniprot.org/citations/28716903 | http://purl.uniprot.org/core/author | "Parekh V.V."xsd:string |
| http://purl.uniprot.org/citations/28716903 | http://purl.uniprot.org/core/author | "Pabbisetty S.K."xsd:string |
| http://purl.uniprot.org/citations/28716903 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28716903 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/28716903 | http://purl.uniprot.org/core/pages | "E6371-E6380"xsd:string |
| http://purl.uniprot.org/citations/28716903 | http://purl.uniprot.org/core/title | "Autophagy-related protein Vps34 controls the homeostasis and function of antigen cross-presenting CD8alphapisup>+pi/sup> dendritic cells."xsd:string |
| http://purl.uniprot.org/citations/28716903 | http://purl.uniprot.org/core/volume | "114"xsd:string |
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