| http://purl.uniprot.org/citations/28716951 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28716951 | http://www.w3.org/2000/01/rdf-schema#comment | "Ca2+- and diacylglycerol (DAG)-activated protein kinase C (cPKC) promotes learning and behavioral plasticity. However, knowledge of in vivo regulation and exact functions of cPKCs that affect behavior is limited. We show that PKC-2, a Caenorhabditis elegans cPKC, is essential for a complex behavior, thermotaxis. C. elegans memorizes a nutrient-associated cultivation temperature (Tc ) and migrates along the Tc within a 17 to 25°C gradient. pkc-2 gene disruption abrogated thermotaxis; a PKC-2 transgene, driven by endogenous pkc-2 promoters, restored thermotaxis behavior in pkc-2-/- animals. Cell-specific manipulation of PKC-2 activity revealed that thermotaxis is controlled by cooperative PKC-2-mediated signaling in both AFD sensory neurons and intestinal cells. Cold-directed migration (cryophilic drive) precedes Tc tracking during thermotaxis. Analysis of temperature-directed behaviors elicited by persistent PKC-2 activation or inhibition in AFD (or intestine) disclosed that PKC-2 regulates initiation and duration of cryophilic drive. In AFD neurons, PKC-2 is a Ca2+ sensor and signal amplifier that operates downstream from cyclic GMP-gated cation channels and distal guanylate cyclases. UNC-18, which regulates neurotransmitter and neuropeptide release from synaptic vesicles, is a critical PKC-2 effector in AFD. UNC-18 variants, created by mutating Ser311 or Ser322, disrupt thermotaxis and suppress PKC-2-dependent cryophilic migration."xsd:string |
| http://purl.uniprot.org/citations/28716951 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00192-17"xsd:string |
| http://purl.uniprot.org/citations/28716951 | http://purl.uniprot.org/core/author | "Land M."xsd:string |
| http://purl.uniprot.org/citations/28716951 | http://purl.uniprot.org/core/author | "Rubin C.S."xsd:string |
| http://purl.uniprot.org/citations/28716951 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28716951 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/28716951 | http://purl.uniprot.org/core/pages | "e00192-17"xsd:string |
| http://purl.uniprot.org/citations/28716951 | http://purl.uniprot.org/core/title | "A Calcium- and Diacylglycerol-Stimulated Protein Kinase C (PKC), Caenorhabditis elegans PKC-2, Links Thermal Signals to Learned Behavior by Acting in Sensory Neurons and Intestinal Cells."xsd:string |
| http://purl.uniprot.org/citations/28716951 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/28716951 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28716951 |
| http://purl.uniprot.org/citations/28716951 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28716951 |
| http://purl.uniprot.org/uniprot/P90980#attribution-1F6D1132E9B40818A9D64F4C33A7008D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/28716951 |
| http://purl.uniprot.org/uniprot/#_A0A4V0IKF6-mappedCitation-28716951 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28716951 |
| http://purl.uniprot.org/uniprot/#_A0A4V6M3D7-mappedCitation-28716951 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28716951 |
| http://purl.uniprot.org/uniprot/#_P34815-mappedCitation-28716951 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28716951 |
| http://purl.uniprot.org/uniprot/#_G8JY36-mappedCitation-28716951 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28716951 |
| http://purl.uniprot.org/uniprot/#_P90980-mappedCitation-28716951 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28716951 |
| http://purl.uniprot.org/uniprot/P90980 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28716951 |
| http://purl.uniprot.org/uniprot/P34815 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28716951 |
| http://purl.uniprot.org/uniprot/A0A4V6M3D7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28716951 |
| http://purl.uniprot.org/uniprot/G8JY36 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28716951 |
| http://purl.uniprot.org/uniprot/A0A4V0IKF6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28716951 |