| http://purl.uniprot.org/citations/28717250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28717250 | http://www.w3.org/2000/01/rdf-schema#comment | "Condensin complexes play crucial roles in chromosome condensation that is a fundamental process to establish the "rod-like" shape of chromosome structure in mitosis. Failure of the chromosome assembly causes chromosome segregation errors and subsequent genomic instability. However, a molecular mechanism that controls condensin function for the chromosomal organization has not been fully understood. Here, we show that the abundance of CAP-H2, one of the condensin II subunits, is fluctuated during the cell cycle in accordance with Plk1 kinase activity. Inhibition of Plk1 leads to Cdc20-mediated degradation of CAP-H2 in mitosis. Plk1 phosphorylation of CAP-H2 at Ser288 is required for the accumulation of CAP-H2 and accurate chromosomal condensation during prophase. These findings suggest that Plk1 phosphorylation regulates condensin II function by modulating CAP-H2 expression levels to facilitate proper mitotic chromosome organization."xsd:string |
| http://purl.uniprot.org/citations/28717250 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-017-05986-7"xsd:string |
| http://purl.uniprot.org/citations/28717250 | http://purl.uniprot.org/core/author | "Yoshida K."xsd:string |
| http://purl.uniprot.org/citations/28717250 | http://purl.uniprot.org/core/author | "Ono M."xsd:string |
| http://purl.uniprot.org/citations/28717250 | http://purl.uniprot.org/core/author | "Kagami Y."xsd:string |
| http://purl.uniprot.org/citations/28717250 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28717250 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/28717250 | http://purl.uniprot.org/core/pages | "5583"xsd:string |
| http://purl.uniprot.org/citations/28717250 | http://purl.uniprot.org/core/title | "Plk1 phosphorylation of CAP-H2 triggers chromosome condensation by condensin II at the early phase of mitosis."xsd:string |
| http://purl.uniprot.org/citations/28717250 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/28717250 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28717250 |
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| http://purl.uniprot.org/uniprot/#_B2R841-mappedCitation-28717250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28717250 |
| http://purl.uniprot.org/uniprot/#_B4E083-mappedCitation-28717250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28717250 |
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| http://purl.uniprot.org/uniprot/B2R841 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28717250 |