| http://purl.uniprot.org/citations/28720486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28720486 | http://www.w3.org/2000/01/rdf-schema#comment | "Affective and cognitive processing of nociception contributes to the development of chronic pain and vice versa, pain may precipitate psychopathologic symptoms. We hypothesized a higher risk for the latter with immanent neurologic diseases and studied this potential interrelationship in progranulin-deficient mice, which are a model for frontotemporal dementia, a disease dominated by behavioral abnormalities in humans. Young naïve progranulin deficient mice behaved normal in tests of short-term memory, anxiety, depression and nociception, but after peripheral nerve injury, they showed attention-deficit and depression-like behavior, over-activity, loss of shelter-seeking, reduced impulse control and compulsive feeding behavior, which did not occur in equally injured controls. Hence, only the interaction of 'pain x progranulin deficiency' resulted in the complex phenotype at young age, but neither pain nor progranulin deficiency alone. A deep proteome analysis of the prefrontal cortex and olfactory bulb revealed progranulin-dependent alterations of proteins involved in synaptic transport, including neurotransmitter transporters of the solute carrier superfamily. In particular, progranulin deficiency was associated with a deficiency of nuclear and synaptic zinc transporters (ZnT9/Slc30a9; ZnT3/Slc30a3) with low plasma zinc. Dietary zinc supplementation partly normalized the attention deficit of progranulin-deficient mice, which was in part reminiscent of autism-like and compulsive behavior of synaptic zinc transporter Znt3-knockout mice. Hence, the molecular studies point to defective zinc transport possibly contributing to progranulin-deficiency-associated psychopathology. Translated to humans, our data suggest that neuropathic pain may precipitate cognitive and psychopathological symptoms of an inherent, still silent neurodegenerative disease."xsd:string |
| http://purl.uniprot.org/citations/28720486 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbadis.2017.07.014"xsd:string |
| http://purl.uniprot.org/citations/28720486 | http://purl.uniprot.org/core/author | "Wittig I."xsd:string |
| http://purl.uniprot.org/citations/28720486 | http://purl.uniprot.org/core/author | "Heidler J."xsd:string |
| http://purl.uniprot.org/citations/28720486 | http://purl.uniprot.org/core/author | "Tegeder I."xsd:string |
| http://purl.uniprot.org/citations/28720486 | http://purl.uniprot.org/core/author | "Altmann C."xsd:string |
| http://purl.uniprot.org/citations/28720486 | http://purl.uniprot.org/core/author | "Albuquerque B."xsd:string |
| http://purl.uniprot.org/citations/28720486 | http://purl.uniprot.org/core/author | "Hardt S."xsd:string |
| http://purl.uniprot.org/citations/28720486 | http://purl.uniprot.org/core/author | "Valek L."xsd:string |
| http://purl.uniprot.org/citations/28720486 | http://purl.uniprot.org/core/author | "Schafer M.K.E."xsd:string |
| http://purl.uniprot.org/citations/28720486 | http://purl.uniprot.org/core/author | "Wilken-Schmitz A."xsd:string |
| http://purl.uniprot.org/citations/28720486 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28720486 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta Mol Basis Dis"xsd:string |
| http://purl.uniprot.org/citations/28720486 | http://purl.uniprot.org/core/pages | "2727-2745"xsd:string |
| http://purl.uniprot.org/citations/28720486 | http://purl.uniprot.org/core/title | "Loss of synaptic zinc transport in progranulin deficient mice may contribute to progranulin-associated psychopathology and chronic pain."xsd:string |
| http://purl.uniprot.org/citations/28720486 | http://purl.uniprot.org/core/volume | "1863"xsd:string |
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