| http://purl.uniprot.org/citations/28723557 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28723557 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28723557 | http://www.w3.org/2000/01/rdf-schema#comment | "The repertoire of the density-regulated protein (DENR) and the malignant T cell-amplified sequence 1 (MCT-1/MCTS1) oncoprotein was recently expanded to include translational control of a specific set of cancer-related mRNAs. DENR and MCT-1 form the heterodimer, which binds to the ribosome and operates at both translation initiation and reinitiation steps, though by a mechanism that is yet unclear. Here, we determined the crystal structure of the human small ribosomal subunit in complex with DENR-MCT-1. The structure reveals the location of the DENR-MCT-1 dimer bound to the small ribosomal subunit. The binding site of the C-terminal domain of DENR on the ribosome has a striking similarity with those of canonical initiation factor 1 (eIF1), which controls the fidelity of translation initiation and scanning. Our findings elucidate how the DENR-MCT-1 dimer interacts with the ribosome and have functional implications for the mechanism of unconventional translation initiation and reinitiation."xsd:string |
| http://purl.uniprot.org/citations/28723557 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2017.06.025"xsd:string |
| http://purl.uniprot.org/citations/28723557 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2017.06.025"xsd:string |
| http://purl.uniprot.org/citations/28723557 | http://purl.uniprot.org/core/author | "Steitz T.A."xsd:string |
| http://purl.uniprot.org/citations/28723557 | http://purl.uniprot.org/core/author | "Steitz T.A."xsd:string |
| http://purl.uniprot.org/citations/28723557 | http://purl.uniprot.org/core/author | "Zhao C."xsd:string |
| http://purl.uniprot.org/citations/28723557 | http://purl.uniprot.org/core/author | "Zhao C."xsd:string |
| http://purl.uniprot.org/citations/28723557 | http://purl.uniprot.org/core/author | "Garber M.B."xsd:string |
| http://purl.uniprot.org/citations/28723557 | http://purl.uniprot.org/core/author | "Garber M.B."xsd:string |
| http://purl.uniprot.org/citations/28723557 | http://purl.uniprot.org/core/author | "Lomakin I.B."xsd:string |
| http://purl.uniprot.org/citations/28723557 | http://purl.uniprot.org/core/author | "Lomakin I.B."xsd:string |
| http://purl.uniprot.org/citations/28723557 | http://purl.uniprot.org/core/author | "Vaidya A.T."xsd:string |
| http://purl.uniprot.org/citations/28723557 | http://purl.uniprot.org/core/author | "Vaidya A.T."xsd:string |
| http://purl.uniprot.org/citations/28723557 | http://purl.uniprot.org/core/author | "Dmitriev S.E."xsd:string |
| http://purl.uniprot.org/citations/28723557 | http://purl.uniprot.org/core/author | "Dmitriev S.E."xsd:string |
| http://purl.uniprot.org/citations/28723557 | http://purl.uniprot.org/core/author | "Stolboushkina E.A."xsd:string |
| http://purl.uniprot.org/citations/28723557 | http://purl.uniprot.org/core/author | "Stolboushkina E.A."xsd:string |
| http://purl.uniprot.org/citations/28723557 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28723557 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28723557 | http://purl.uniprot.org/core/name | "Cell Rep."xsd:string |
| http://purl.uniprot.org/citations/28723557 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/28723557 | http://purl.uniprot.org/core/pages | "521-528"xsd:string |
| http://purl.uniprot.org/citations/28723557 | http://purl.uniprot.org/core/pages | "521-528"xsd:string |