| http://purl.uniprot.org/citations/28723569 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28723569 | http://www.w3.org/2000/01/rdf-schema#comment | "X-linked Inhibitor of Apoptosis (XIAP) deficiency predisposes people to pathogen-associated hyperinflammation. Upon XIAP loss, Toll-like receptor (TLR) ligation triggers RIPK3-caspase-8-mediated IL-1β activation and death in myeloid cells. How XIAP suppresses these events remains unclear. Here, we show that TLR-MyD88 causes the proteasomal degradation of the related IAP, cIAP1, and its adaptor, TRAF2, by inducing TNF and TNF Receptor 2 (TNFR2) signaling. Genetically, we define that myeloid-specific cIAP1 loss promotes TLR-induced RIPK3-caspase-8 and IL-1β activity in the absence of XIAP. Importantly, deletion of TNFR2 in XIAP-deficient cells limited TLR-MyD88-induced cIAP1-TRAF2 degradation, cell death, and IL-1β activation. In contrast to TLR-MyD88, TLR-TRIF-induced interferon (IFN)β inhibited cIAP1 loss and consequent cell death. These data reveal how, upon XIAP deficiency, a TLR-TNF-TNFR2 axis drives cIAP1-TRAF2 degradation to allow TLR or TNFR1 activation of RIPK3-caspase-8 and IL-1β. This mechanism may explain why XIAP-deficient patients can exhibit symptoms reminiscent of patients with activating inflammasome mutations."xsd:string |
| http://purl.uniprot.org/citations/28723569 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2017.06.073"xsd:string |
| http://purl.uniprot.org/citations/28723569 | http://purl.uniprot.org/core/author | "Hall C."xsd:string |
| http://purl.uniprot.org/citations/28723569 | http://purl.uniprot.org/core/author | "Pang K.C."xsd:string |
| http://purl.uniprot.org/citations/28723569 | http://purl.uniprot.org/core/author | "Schroder K."xsd:string |
| http://purl.uniprot.org/citations/28723569 | http://purl.uniprot.org/core/author | "Zhan Y."xsd:string |
| http://purl.uniprot.org/citations/28723569 | http://purl.uniprot.org/core/author | "Nguyen T.A."xsd:string |
| http://purl.uniprot.org/citations/28723569 | http://purl.uniprot.org/core/author | "Chen K.W."xsd:string |
| http://purl.uniprot.org/citations/28723569 | http://purl.uniprot.org/core/author | "Vaux D.L."xsd:string |
| http://purl.uniprot.org/citations/28723569 | http://purl.uniprot.org/core/author | "Vince J.E."xsd:string |
| http://purl.uniprot.org/citations/28723569 | http://purl.uniprot.org/core/author | "Lawlor K.E."xsd:string |
| http://purl.uniprot.org/citations/28723569 | http://purl.uniprot.org/core/author | "Yabal M."xsd:string |
| http://purl.uniprot.org/citations/28723569 | http://purl.uniprot.org/core/author | "Silke J."xsd:string |
| http://purl.uniprot.org/citations/28723569 | http://purl.uniprot.org/core/author | "D'Silva D.B."xsd:string |
| http://purl.uniprot.org/citations/28723569 | http://purl.uniprot.org/core/author | "Jost P.J."xsd:string |
| http://purl.uniprot.org/citations/28723569 | http://purl.uniprot.org/core/author | "Feltham R."xsd:string |
| http://purl.uniprot.org/citations/28723569 | http://purl.uniprot.org/core/author | "Conos S.A."xsd:string |
| http://purl.uniprot.org/citations/28723569 | http://purl.uniprot.org/core/author | "Chatfield S.M."xsd:string |
| http://purl.uniprot.org/citations/28723569 | http://purl.uniprot.org/core/author | "Grass C."xsd:string |
| http://purl.uniprot.org/citations/28723569 | http://purl.uniprot.org/core/author | "Vince A.J."xsd:string |
| http://purl.uniprot.org/citations/28723569 | http://purl.uniprot.org/core/author | "Ziehe S."xsd:string |
| http://purl.uniprot.org/citations/28723569 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28723569 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/28723569 | http://purl.uniprot.org/core/pages | "668-682"xsd:string |