| http://purl.uniprot.org/citations/28724742 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28724742 | http://www.w3.org/2000/01/rdf-schema#comment | "This study explored the role of irisin as a new pancreatic β-cell secretagogue and survival factor and its potential role in the communication between skeletal muscle and pancreatic β-cells under lipotoxic conditions. Recombinant irisin stimulated insulin biosynthesis and glucose-stimulated insulin secretion (GSIS) in a PKA-dependent manner and prevented saturated fatty acid-induced apoptosis in human and rat pancreatic β-cells, as well as in human and murine pancreatic islets, via AKT/BCL2 signaling. Treatment of myotubes with 0.5 mmol/L palmitate for 4 h, but not with oleate, promoted an increase in irisin release in the culture medium. Moreover, increased serum levels of irisin were observed in mice fed with a high-fat diet. Mouse serum rich in irisin and the conditioned medium from myotubes exposed to palmitate for 4 h significantly reduced apoptosis of murine pancreatic islets and insulin-secreting INS-1E cells, respectively, and this was abrogated in the presence of an irisin-neutralizing antibody. Finally, in vivo administration of irisin improved GSIS and increased β-cell proliferation. In conclusion, irisin can promote β-cell survival and enhance GSIS and may thus participate in the communication between skeletal muscle and β-cells under conditions of excess saturated fatty acids."xsd:string |
| http://purl.uniprot.org/citations/28724742 | http://purl.org/dc/terms/identifier | "doi:10.2337/db17-0002"xsd:string |
| http://purl.uniprot.org/citations/28724742 | http://purl.uniprot.org/core/author | "Bugliani M."xsd:string |
| http://purl.uniprot.org/citations/28724742 | http://purl.uniprot.org/core/author | "Marchetti P."xsd:string |
| http://purl.uniprot.org/citations/28724742 | http://purl.uniprot.org/core/author | "Giorgino F."xsd:string |
| http://purl.uniprot.org/citations/28724742 | http://purl.uniprot.org/core/author | "Laviola L."xsd:string |
| http://purl.uniprot.org/citations/28724742 | http://purl.uniprot.org/core/author | "Biondi G."xsd:string |
| http://purl.uniprot.org/citations/28724742 | http://purl.uniprot.org/core/author | "Porreca I."xsd:string |
| http://purl.uniprot.org/citations/28724742 | http://purl.uniprot.org/core/author | "Spagnuolo R."xsd:string |
| http://purl.uniprot.org/citations/28724742 | http://purl.uniprot.org/core/author | "Perrini S."xsd:string |
| http://purl.uniprot.org/citations/28724742 | http://purl.uniprot.org/core/author | "Natalicchio A."xsd:string |
| http://purl.uniprot.org/citations/28724742 | http://purl.uniprot.org/core/author | "Cignarelli A."xsd:string |
| http://purl.uniprot.org/citations/28724742 | http://purl.uniprot.org/core/author | "Labarbuta R."xsd:string |
| http://purl.uniprot.org/citations/28724742 | http://purl.uniprot.org/core/author | "Marrano N."xsd:string |
| http://purl.uniprot.org/citations/28724742 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28724742 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/28724742 | http://purl.uniprot.org/core/pages | "2849-2856"xsd:string |
| http://purl.uniprot.org/citations/28724742 | http://purl.uniprot.org/core/title | "The Myokine Irisin Is Released in Response to Saturated Fatty Acids and Promotes Pancreatic beta-Cell Survival and Insulin Secretion."xsd:string |
| http://purl.uniprot.org/citations/28724742 | http://purl.uniprot.org/core/volume | "66"xsd:string |
| http://purl.uniprot.org/citations/28724742 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28724742 |
| http://purl.uniprot.org/citations/28724742 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28724742 |
| http://purl.uniprot.org/uniprot/#_A0A8A2HEV9-mappedCitation-28724742 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28724742 |
| http://purl.uniprot.org/uniprot/#_Q8K3V5-mappedCitation-28724742 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28724742 |
| http://purl.uniprot.org/uniprot/#_Q8K4Z2-mappedCitation-28724742 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28724742 |