| http://purl.uniprot.org/citations/28729362 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28729362 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveMolecular pathways governing blood vessel patterning are vital to vertebrate development. Because of their ability to counteract proangiogenic factors, antiangiogenic secreted Sema3 (class 3 semaphorins) control embryonic vascular morphogenesis. However, if and how Sema3 may play a role in the control of extraembryonic vascular development is presently unknown.Approach and resultsBy characterizing genetically modified mice, here, we show that surprisingly Sema3F acts instead as a selective extraembryonic, but not intraembryonic proangiogenic cue. Both in vivo and in vitro, in visceral yolk sac epithelial cells, Sema3F signals to inhibit the phosphorylation-dependent degradation of Myc, a transcription factor that drives the expression of proangiogenic genes, such as the microRNA cluster 17/92. In Sema3f-null yolk sacs, the transcription of Myc-regulated microRNA 17/92 cluster members is impaired, and the synthesis of Myc and microRNA 17/92 foremost antiangiogenic target Thbs1 (thrombospondin 1) is increased, whereas Vegf (vascular endothelial growth factor) signaling is inhibited in yolk sac endothelial cells. Consistently, exogenous recombinant Sema3F inhibits the phosphorylation-dependent degradation of Myc and the synthesis of Thbs1 in mouse F9 teratocarcinoma stem cells that were in vitro differentiated in visceral yolk sac epithelial cells. Sema3f-/- mice placentas are also highly anemic and abnormally vascularized.ConclusionsSema3F functions as an unconventional Sema3 that promotes extraembryonic angiogenesis by inhibiting the Myc-regulated synthesis of Thbs1 in visceral yolk sac epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/28729362 | http://purl.org/dc/terms/identifier | "doi:10.1161/atvbaha.117.308226"xsd:string |
| http://purl.uniprot.org/citations/28729362 | http://purl.uniprot.org/core/author | "Bussolino F."xsd:string |
| http://purl.uniprot.org/citations/28729362 | http://purl.uniprot.org/core/author | "Visintin A."xsd:string |
| http://purl.uniprot.org/citations/28729362 | http://purl.uniprot.org/core/author | "Giraudo E."xsd:string |
| http://purl.uniprot.org/citations/28729362 | http://purl.uniprot.org/core/author | "Serini G."xsd:string |
| http://purl.uniprot.org/citations/28729362 | http://purl.uniprot.org/core/author | "Valdembri D."xsd:string |
| http://purl.uniprot.org/citations/28729362 | http://purl.uniprot.org/core/author | "Maione F."xsd:string |
| http://purl.uniprot.org/citations/28729362 | http://purl.uniprot.org/core/author | "Regano D."xsd:string |
| http://purl.uniprot.org/citations/28729362 | http://purl.uniprot.org/core/author | "Clapero F."xsd:string |
| http://purl.uniprot.org/citations/28729362 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28729362 | http://purl.uniprot.org/core/name | "Arterioscler Thromb Vasc Biol"xsd:string |
| http://purl.uniprot.org/citations/28729362 | http://purl.uniprot.org/core/pages | "1710-1721"xsd:string |
| http://purl.uniprot.org/citations/28729362 | http://purl.uniprot.org/core/title | "Sema3F (Semaphorin 3F) Selectively Drives an Extraembryonic Proangiogenic Program."xsd:string |
| http://purl.uniprot.org/citations/28729362 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/28729362 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28729362 |
| http://purl.uniprot.org/citations/28729362 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28729362 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YW11-mappedCitation-28729362 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28729362 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JDR2-mappedCitation-28729362 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28729362 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWS0-mappedCitation-28729362 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28729362 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YX80-mappedCitation-28729362 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28729362 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXX2-mappedCitation-28729362 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28729362 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YY06-mappedCitation-28729362 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28729362 |
| http://purl.uniprot.org/uniprot/#_D3Z2A7-mappedCitation-28729362 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28729362 |