| http://purl.uniprot.org/citations/28731405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28731405 | http://www.w3.org/2000/01/rdf-schema#comment | "Aberrant NMDA receptor (NMDAR) activity contributes to several neurological disorders, but direct antagonism is poorly tolerated therapeutically. The GluN2B cytoplasmic C-terminal domain (CTD) represents an alternative therapeutic target since it potentiates excitotoxic signaling. The key GluN2B CTD-centred event in excitotoxicity is proposed to involve its phosphorylation at Ser-1303 by Dapk1, that is blocked by a neuroprotective cell-permeable peptide mimetic of the region. Contrary to this model, we find that excitotoxicity can proceed without increased Ser-1303 phosphorylation, and is unaffected by Dapk1 deficiency in vitro or following ischemia in vivo. Pharmacological analysis of the aforementioned neuroprotective peptide revealed that it acts in a sequence-independent manner as an open-channel NMDAR antagonist at or near the Mg2+ site, due to its high net positive charge. Thus, GluN2B-driven excitotoxic signaling can proceed independently of Dapk1 or altered Ser-1303 phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/28731405 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.17161"xsd:string |
| http://purl.uniprot.org/citations/28731405 | http://purl.uniprot.org/core/author | "Grant S.G.N."xsd:string |
| http://purl.uniprot.org/citations/28731405 | http://purl.uniprot.org/core/author | "Baxter P."xsd:string |
| http://purl.uniprot.org/citations/28731405 | http://purl.uniprot.org/core/author | "McKay S."xsd:string |
| http://purl.uniprot.org/citations/28731405 | http://purl.uniprot.org/core/author | "Gillingwater T.H."xsd:string |
| http://purl.uniprot.org/citations/28731405 | http://purl.uniprot.org/core/author | "Wishart T.M."xsd:string |
| http://purl.uniprot.org/citations/28731405 | http://purl.uniprot.org/core/author | "Ryan T.J."xsd:string |
| http://purl.uniprot.org/citations/28731405 | http://purl.uniprot.org/core/author | "Komiyama N.H."xsd:string |
| http://purl.uniprot.org/citations/28731405 | http://purl.uniprot.org/core/author | "Hardingham G.E."xsd:string |
| http://purl.uniprot.org/citations/28731405 | http://purl.uniprot.org/core/author | "McColl B.W."xsd:string |
| http://purl.uniprot.org/citations/28731405 | http://purl.uniprot.org/core/author | "Manson J.C."xsd:string |
| http://purl.uniprot.org/citations/28731405 | http://purl.uniprot.org/core/author | "Carpanini S.M."xsd:string |
| http://purl.uniprot.org/citations/28731405 | http://purl.uniprot.org/core/author | "McQueen J."xsd:string |
| http://purl.uniprot.org/citations/28731405 | http://purl.uniprot.org/core/author | "Marwick K."xsd:string |
| http://purl.uniprot.org/citations/28731405 | http://purl.uniprot.org/core/author | "Wyllie D.J.A."xsd:string |
| http://purl.uniprot.org/citations/28731405 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28731405 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/28731405 | http://purl.uniprot.org/core/pages | "e17161"xsd:string |
| http://purl.uniprot.org/citations/28731405 | http://purl.uniprot.org/core/title | "Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1."xsd:string |
| http://purl.uniprot.org/citations/28731405 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/28731405 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28731405 |
| http://purl.uniprot.org/citations/28731405 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28731405 |
| http://purl.uniprot.org/uniprot/#_A0A286YDD8-mappedCitation-28731405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28731405 |