| http://purl.uniprot.org/citations/28732559 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28732559 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor necrosis factor-α (TNF-α) is suggested to induce mitochondrial dysfunction and apoptosis of renal tubular epithelial cells that possibly exacerbates renal function in chronic kidney disease (CKD). Here we investigated whether suppressor of cytokine signaling-1 (SOCS-1), an inhibitor of cytokine signaling, was involved in TNF-α-induced human renal tubular epithelial cells (HKCs) oxidative stress and apoptosis. TNF-α promoted the protein and mRNA expression of SOCS-1 in a time and dose dependent manner, along with increased cell apoptosis and activation of apoptosis signal regulating kinase-1(ASK1) in HKCs. Furthermore, overexpression of SOCS-1 in HKCs reduced TNF-α-mediated oxidative stress and apoptosis. Meanwhile, We also found that overexpression of SOCS-1 could regulate the activity of JAK/STAT signaling pathway. In addition, a specific JAK2 inhibitor, AG490, that both attenuated TNF-α-induced oxidative stress, also reduced apoptosis. Taken together, overexpression of SOCS-1 prevented TNF-α-mediated cell oxidative stress and apoptosis may be via suppression of JAK/STAT signaling pathway activation in HKCs."xsd:string |
| http://purl.uniprot.org/citations/28732559 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.tice.2017.06.005"xsd:string |
| http://purl.uniprot.org/citations/28732559 | http://purl.uniprot.org/core/author | "Du Y."xsd:string |
| http://purl.uniprot.org/citations/28732559 | http://purl.uniprot.org/core/author | "Ren Y."xsd:string |
| http://purl.uniprot.org/citations/28732559 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/28732559 | http://purl.uniprot.org/core/author | "Wu H."xsd:string |
| http://purl.uniprot.org/citations/28732559 | http://purl.uniprot.org/core/author | "Wei J."xsd:string |
| http://purl.uniprot.org/citations/28732559 | http://purl.uniprot.org/core/author | "Yao F."xsd:string |
| http://purl.uniprot.org/citations/28732559 | http://purl.uniprot.org/core/author | "Duan H."xsd:string |
| http://purl.uniprot.org/citations/28732559 | http://purl.uniprot.org/core/author | "Du C."xsd:string |
| http://purl.uniprot.org/citations/28732559 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28732559 | http://purl.uniprot.org/core/name | "Tissue Cell"xsd:string |
| http://purl.uniprot.org/citations/28732559 | http://purl.uniprot.org/core/pages | "537-544"xsd:string |
| http://purl.uniprot.org/citations/28732559 | http://purl.uniprot.org/core/title | "SOCS-1 is involved in TNF-alpha-induced mitochondrial dysfunction and apoptosis in renal tubular epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/28732559 | http://purl.uniprot.org/core/volume | "49"xsd:string |
| http://purl.uniprot.org/citations/28732559 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28732559 |
| http://purl.uniprot.org/citations/28732559 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28732559 |
| http://purl.uniprot.org/uniprot/#_O15524-mappedCitation-28732559 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28732559 |
| http://purl.uniprot.org/uniprot/#_Q4JHT5-mappedCitation-28732559 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28732559 |
| http://purl.uniprot.org/uniprot/O15524 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28732559 |
| http://purl.uniprot.org/uniprot/Q4JHT5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28732559 |