| http://purl.uniprot.org/citations/28733471 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28733471 | http://www.w3.org/2000/01/rdf-schema#comment | "Specific gut commensal bacteria improve host health by eliciting mutualistic regulatory T (Treg) cell responses. However, the bacteria that induce effector T (Teff) cells during inflammation are unclear. We addressed this by analyzing bacterial-reactive T cell receptor (TCR) transgenic cells and TCR repertoires in a murine colitis model. Unexpectedly, we found that mucosal-associated Helicobacter species triggered both Treg cell responses during homeostasis and Teff cell responses during colitis, as suggested by an increased overlap between the Teff/Treg TCR repertoires with colitis. Four of six Treg TCRs tested recognized mucosal-associated Helicobacter species in vitro and in vivo. By contrast, the marked expansion of luminal Bacteroides species seen during colitis did not trigger a commensurate Teff cell response. Unlike other Treg cell-inducing bacteria, Helicobacter species are known pathobionts and cause disease in immunodeficient mice. Thus, our study suggests a model in which mucosal bacteria elicit context-dependent Treg or Teff cell responses to facilitate intestinal tolerance or inflammation."xsd:string |
| http://purl.uniprot.org/citations/28733471 | http://purl.org/dc/terms/identifier | "doi:10.1126/sciimmunol.aal5068"xsd:string |
| http://purl.uniprot.org/citations/28733471 | http://purl.uniprot.org/core/author | "Shen Z."xsd:string |
| http://purl.uniprot.org/citations/28733471 | http://purl.uniprot.org/core/author | "Fox J.G."xsd:string |
| http://purl.uniprot.org/citations/28733471 | http://purl.uniprot.org/core/author | "Peng Y."xsd:string |
| http://purl.uniprot.org/citations/28733471 | http://purl.uniprot.org/core/author | "Stappenbeck T.S."xsd:string |
| http://purl.uniprot.org/citations/28733471 | http://purl.uniprot.org/core/author | "Tanoue T."xsd:string |
| http://purl.uniprot.org/citations/28733471 | http://purl.uniprot.org/core/author | "Honda K."xsd:string |
| http://purl.uniprot.org/citations/28733471 | http://purl.uniprot.org/core/author | "Peterson D.A."xsd:string |
| http://purl.uniprot.org/citations/28733471 | http://purl.uniprot.org/core/author | "Newberry R.D."xsd:string |
| http://purl.uniprot.org/citations/28733471 | http://purl.uniprot.org/core/author | "Solomon B.D."xsd:string |
| http://purl.uniprot.org/citations/28733471 | http://purl.uniprot.org/core/author | "Elson C.O."xsd:string |
| http://purl.uniprot.org/citations/28733471 | http://purl.uniprot.org/core/author | "Narushima S."xsd:string |
| http://purl.uniprot.org/citations/28733471 | http://purl.uniprot.org/core/author | "Kau A.L."xsd:string |
| http://purl.uniprot.org/citations/28733471 | http://purl.uniprot.org/core/author | "Perry J.S.A."xsd:string |
| http://purl.uniprot.org/citations/28733471 | http://purl.uniprot.org/core/author | "Hsieh C.S."xsd:string |
| http://purl.uniprot.org/citations/28733471 | http://purl.uniprot.org/core/author | "Knoop K.A."xsd:string |
| http://purl.uniprot.org/citations/28733471 | http://purl.uniprot.org/core/author | "Rengarajan S."xsd:string |
| http://purl.uniprot.org/citations/28733471 | http://purl.uniprot.org/core/author | "Ai T.L."xsd:string |
| http://purl.uniprot.org/citations/28733471 | http://purl.uniprot.org/core/author | "Chai J.N."xsd:string |
| http://purl.uniprot.org/citations/28733471 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28733471 | http://purl.uniprot.org/core/name | "Sci Immunol"xsd:string |
| http://purl.uniprot.org/citations/28733471 | http://purl.uniprot.org/core/pages | "eaal5068"xsd:string |
| http://purl.uniprot.org/citations/28733471 | http://purl.uniprot.org/core/title | "Helicobacter species are potent drivers of colonic T cell responses in homeostasis and inflammation."xsd:string |