| http://purl.uniprot.org/citations/28737769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28737769 | http://www.w3.org/2000/01/rdf-schema#comment | "After influenza infection, lineage-negative epithelial progenitors (LNEPs) exhibit a binary response to reconstitute epithelial barriers: activating a Notch-dependent ΔNp63/cytokeratin 5 (Krt5) remodelling program or differentiating into alveolar type II cells (AEC2s). Here we show that local lung hypoxia, through hypoxia-inducible factor (HIF1α), drives Notch signalling and Krt5pos basal-like cell expansion. Single-cell transcriptional profiling of human AEC2s from fibrotic lungs revealed a hypoxic subpopulation with activated Notch, suppressed surfactant protein C (SPC), and transdifferentiation toward a Krt5pos basal-like state. Activated murine Krt5pos LNEPs and diseased human AEC2s upregulate strikingly similar core pathways underlying migration and squamous metaplasia. While robust, HIF1α-driven metaplasia is ultimately inferior to AEC2 reconstitution in restoring normal lung function. HIF1α deletion or enhanced Wnt/β-catenin activity in Sox2pos LNEPs blocks Notch and Krt5 activation, instead promoting rapid AEC2 differentiation and migration and improving the quality of alveolar repair."xsd:string |
| http://purl.uniprot.org/citations/28737769 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb3580"xsd:string |
| http://purl.uniprot.org/citations/28737769 | http://purl.uniprot.org/core/author | "Wei Y."xsd:string |
| http://purl.uniprot.org/citations/28737769 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/28737769 | http://purl.uniprot.org/core/author | "Xi Y."xsd:string |
| http://purl.uniprot.org/citations/28737769 | http://purl.uniprot.org/core/author | "Kim T."xsd:string |
| http://purl.uniprot.org/citations/28737769 | http://purl.uniprot.org/core/author | "Lee D.K."xsd:string |
| http://purl.uniprot.org/citations/28737769 | http://purl.uniprot.org/core/author | "Matthay M.A."xsd:string |
| http://purl.uniprot.org/citations/28737769 | http://purl.uniprot.org/core/author | "Chapman H.A."xsd:string |
| http://purl.uniprot.org/citations/28737769 | http://purl.uniprot.org/core/author | "Tan V."xsd:string |
| http://purl.uniprot.org/citations/28737769 | http://purl.uniprot.org/core/author | "Shannon J.M."xsd:string |
| http://purl.uniprot.org/citations/28737769 | http://purl.uniprot.org/core/author | "Jackson J.R."xsd:string |
| http://purl.uniprot.org/citations/28737769 | http://purl.uniprot.org/core/author | "Vaughan A.E."xsd:string |
| http://purl.uniprot.org/citations/28737769 | http://purl.uniprot.org/core/author | "Brumwell A.N."xsd:string |
| http://purl.uniprot.org/citations/28737769 | http://purl.uniprot.org/core/author | "Gotts J.E."xsd:string |
| http://purl.uniprot.org/citations/28737769 | http://purl.uniprot.org/core/author | "Driver I.H."xsd:string |
| http://purl.uniprot.org/citations/28737769 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28737769 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/28737769 | http://purl.uniprot.org/core/pages | "904-914"xsd:string |
| http://purl.uniprot.org/citations/28737769 | http://purl.uniprot.org/core/title | "Local lung hypoxia determines epithelial fate decisions during alveolar regeneration."xsd:string |
| http://purl.uniprot.org/citations/28737769 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/28737769 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28737769 |
| http://purl.uniprot.org/citations/28737769 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28737769 |
| http://purl.uniprot.org/uniprot/#_D3Z7K2-mappedCitation-28737769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28737769 |