| http://purl.uniprot.org/citations/28739679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28739679 | http://www.w3.org/2000/01/rdf-schema#comment | "The position of the mitotic spindle is tightly controlled in animal cells as it determines the plane and orientation of cell division. Contacts between cytoplasmic dynein and astral microtubules (MTs) at the cell cortex generate pulling forces that position the spindle. An evolutionarily conserved Gα-GPR-1/2Pins/LGN-LIN-5Mud/NuMA cortical complex interacts with dynein and is required for pulling force generation, but the dynamics of this process remain unclear. In this study, by fluorescently labeling endogenous proteins in Caenorhabditis elegans embryos, we show that dynein exists in two distinct cortical populations. One population directly depends on LIN-5, whereas the other is concentrated at MT plus ends and depends on end-binding (EB) proteins. Knockout mutants lacking all EBs are viable and fertile and display normal pulling forces and spindle positioning. However, EB protein-dependent dynein plus end tracking was found to contribute to force generation in embryos with a partially perturbed dynein function, indicating the existence of two mechanisms that together create a highly robust force-generating system."xsd:string |
| http://purl.uniprot.org/citations/28739679 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201607038"xsd:string |
| http://purl.uniprot.org/citations/28739679 | http://purl.uniprot.org/core/author | "Grigoriev I."xsd:string |
| http://purl.uniprot.org/citations/28739679 | http://purl.uniprot.org/core/author | "Schmidt R."xsd:string |
| http://purl.uniprot.org/citations/28739679 | http://purl.uniprot.org/core/author | "Akhmanova A."xsd:string |
| http://purl.uniprot.org/citations/28739679 | http://purl.uniprot.org/core/author | "Katrukha E.A."xsd:string |
| http://purl.uniprot.org/citations/28739679 | http://purl.uniprot.org/core/author | "van den Heuvel S."xsd:string |
| http://purl.uniprot.org/citations/28739679 | http://purl.uniprot.org/core/author | "Fielmich L.E."xsd:string |
| http://purl.uniprot.org/citations/28739679 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28739679 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/28739679 | http://purl.uniprot.org/core/pages | "2777-2793"xsd:string |
| http://purl.uniprot.org/citations/28739679 | http://purl.uniprot.org/core/title | "Two populations of cytoplasmic dynein contribute to spindle positioning in C. elegans embryos."xsd:string |
| http://purl.uniprot.org/citations/28739679 | http://purl.uniprot.org/core/volume | "216"xsd:string |
| http://purl.uniprot.org/citations/28739679 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28739679 |
| http://purl.uniprot.org/citations/28739679 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28739679 |
| http://purl.uniprot.org/uniprot/#_A0A163VTS9-mappedCitation-28739679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28739679 |
| http://purl.uniprot.org/uniprot/#_P45970-mappedCitation-28739679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28739679 |
| http://purl.uniprot.org/uniprot/#_Q19020-mappedCitation-28739679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28739679 |
| http://purl.uniprot.org/uniprot/Q19020 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28739679 |
| http://purl.uniprot.org/uniprot/P45970 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28739679 |
| http://purl.uniprot.org/uniprot/A0A163VTS9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28739679 |