| http://purl.uniprot.org/citations/28740084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28740084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28740084 | http://www.w3.org/2000/01/rdf-schema#comment | "The Cardiomyopathy-associated gene 5 (Cmya5) encodes myospryn, a large tripartite motif (TRIM)-related protein found predominantly in cardiac and skeletal muscle. Cmya5 is an expression biomarker for a number of diseases affecting striated muscle and may also be a schizophrenia risk gene. To further understand the function of myospryn in striated muscle, we searched for additional myospryn paralogs. Here we identify a novel muscle-expressed TRIM-related protein minispryn, encoded by Fsd2, that has extensive sequence similarity with the C-terminus of myospryn. Cmya5 and Fsd2 appear to have originated by a chromosomal duplication and are found within evolutionarily-conserved gene clusters on different chromosomes. Using immunoaffinity purification and mass spectrometry we show that minispryn co-purifies with myospryn and the major cardiac ryanodine receptor (RyR2) from heart. Accordingly, myospryn, minispryn and RyR2 co-localise at the junctional sarcoplasmic reticulum of isolated cardiomyocytes. Myospryn redistributes RyR2 into clusters when co-expressed in heterologous cells whereas minispryn lacks this activity. Together these data suggest a novel role for the myospryn complex in the assembly of ryanodine receptor clusters in striated muscle."xsd:string |
| http://purl.uniprot.org/citations/28740084 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-017-06395-6"xsd:string |
| http://purl.uniprot.org/citations/28740084 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-017-06395-6"xsd:string |
| http://purl.uniprot.org/citations/28740084 | http://purl.uniprot.org/core/author | "Lai F.A."xsd:string |
| http://purl.uniprot.org/citations/28740084 | http://purl.uniprot.org/core/author | "Lai F.A."xsd:string |
| http://purl.uniprot.org/citations/28740084 | http://purl.uniprot.org/core/author | "Benson M.A."xsd:string |
| http://purl.uniprot.org/citations/28740084 | http://purl.uniprot.org/core/author | "Benson M.A."xsd:string |
| http://purl.uniprot.org/citations/28740084 | http://purl.uniprot.org/core/author | "Blake D.J."xsd:string |
| http://purl.uniprot.org/citations/28740084 | http://purl.uniprot.org/core/author | "Blake D.J."xsd:string |
| http://purl.uniprot.org/citations/28740084 | http://purl.uniprot.org/core/author | "Tinsley C.L."xsd:string |
| http://purl.uniprot.org/citations/28740084 | http://purl.uniprot.org/core/author | "Tinsley C.L."xsd:string |
| http://purl.uniprot.org/citations/28740084 | http://purl.uniprot.org/core/author | "Ehler E."xsd:string |
| http://purl.uniprot.org/citations/28740084 | http://purl.uniprot.org/core/author | "Ehler E."xsd:string |
| http://purl.uniprot.org/citations/28740084 | http://purl.uniprot.org/core/author | "Waite A.J."xsd:string |
| http://purl.uniprot.org/citations/28740084 | http://purl.uniprot.org/core/author | "Waite A.J."xsd:string |
| http://purl.uniprot.org/citations/28740084 | http://purl.uniprot.org/core/author | "Carlisle F.A."xsd:string |
| http://purl.uniprot.org/citations/28740084 | http://purl.uniprot.org/core/author | "Carlisle F.A."xsd:string |
| http://purl.uniprot.org/citations/28740084 | http://purl.uniprot.org/core/author | "George C.H."xsd:string |
| http://purl.uniprot.org/citations/28740084 | http://purl.uniprot.org/core/author | "George C.H."xsd:string |
| http://purl.uniprot.org/citations/28740084 | http://purl.uniprot.org/core/author | "Martin-Rendon E."xsd:string |
| http://purl.uniprot.org/citations/28740084 | http://purl.uniprot.org/core/author | "Martin-Rendon E."xsd:string |
| http://purl.uniprot.org/citations/28740084 | http://purl.uniprot.org/core/author | "Sweet S.M.M."xsd:string |
| http://purl.uniprot.org/citations/28740084 | http://purl.uniprot.org/core/author | "Sweet S.M.M."xsd:string |