| http://purl.uniprot.org/citations/28741611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28741611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28741611 | http://www.w3.org/2000/01/rdf-schema#comment | "Many antibiotics stop bacterial growth by inhibiting different steps of protein synthesis. However, no specific inhibitors of translation termination are known. Proline-rich antimicrobial peptides, a component of the antibacterial defense system of multicellular organisms, interfere with bacterial growth by inhibiting translation. Here we show that Api137, a derivative of the insect-produced antimicrobial peptide apidaecin, arrests terminating ribosomes using a unique mechanism of action. Api137 binds to the Escherichia coli ribosome and traps release factor (RF) RF1 or RF2 subsequent to the release of the nascent polypeptide chain. A high-resolution cryo-EM structure of the ribosome complexed with RF1 and Api137 reveals the molecular interactions that lead to RF trapping. Api137-mediated depletion of the cellular pool of free release factors causes the majority of ribosomes to stall at stop codons before polypeptide release, thereby resulting in a global shutdown of translation termination."xsd:string |
| http://purl.uniprot.org/citations/28741611 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.3439"xsd:string |
| http://purl.uniprot.org/citations/28741611 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.3439"xsd:string |
| http://purl.uniprot.org/citations/28741611 | http://purl.uniprot.org/core/author | "Rodnina M.V."xsd:string |
| http://purl.uniprot.org/citations/28741611 | http://purl.uniprot.org/core/author | "Rodnina M.V."xsd:string |
| http://purl.uniprot.org/citations/28741611 | http://purl.uniprot.org/core/author | "Beckmann R."xsd:string |
| http://purl.uniprot.org/citations/28741611 | http://purl.uniprot.org/core/author | "Beckmann R."xsd:string |
| http://purl.uniprot.org/citations/28741611 | http://purl.uniprot.org/core/author | "Berninghausen O."xsd:string |
| http://purl.uniprot.org/citations/28741611 | http://purl.uniprot.org/core/author | "Berninghausen O."xsd:string |
| http://purl.uniprot.org/citations/28741611 | http://purl.uniprot.org/core/author | "Wilson D.N."xsd:string |
| http://purl.uniprot.org/citations/28741611 | http://purl.uniprot.org/core/author | "Wilson D.N."xsd:string |
| http://purl.uniprot.org/citations/28741611 | http://purl.uniprot.org/core/author | "Vazquez-Laslop N."xsd:string |
| http://purl.uniprot.org/citations/28741611 | http://purl.uniprot.org/core/author | "Vazquez-Laslop N."xsd:string |
| http://purl.uniprot.org/citations/28741611 | http://purl.uniprot.org/core/author | "Mankin A.S."xsd:string |
| http://purl.uniprot.org/citations/28741611 | http://purl.uniprot.org/core/author | "Mankin A.S."xsd:string |
| http://purl.uniprot.org/citations/28741611 | http://purl.uniprot.org/core/author | "Klepacki D."xsd:string |
| http://purl.uniprot.org/citations/28741611 | http://purl.uniprot.org/core/author | "Klepacki D."xsd:string |
| http://purl.uniprot.org/citations/28741611 | http://purl.uniprot.org/core/author | "Graf M."xsd:string |
| http://purl.uniprot.org/citations/28741611 | http://purl.uniprot.org/core/author | "Graf M."xsd:string |
| http://purl.uniprot.org/citations/28741611 | http://purl.uniprot.org/core/author | "Maracci C."xsd:string |
| http://purl.uniprot.org/citations/28741611 | http://purl.uniprot.org/core/author | "Maracci C."xsd:string |
| http://purl.uniprot.org/citations/28741611 | http://purl.uniprot.org/core/author | "Karki P."xsd:string |
| http://purl.uniprot.org/citations/28741611 | http://purl.uniprot.org/core/author | "Karki P."xsd:string |