| http://purl.uniprot.org/citations/28743268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28743268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28743268 | http://www.w3.org/2000/01/rdf-schema#comment | "Haploinsufficiency of GRN, the gene encoding progranulin (PGRN), causes frontotemporal lobar degeneration (FTLD), the second most common cause of early-onset dementia. Receptor-mediated lysosomal targeting has been shown to regulate brain PGRN levels, and complete deficiency of PGRN is a direct cause of neuronal ceroid lipofuscinosis (NCL), a lysosomal storage disease. Here we show that the lysosomal cysteine protease cathepsin L (Cat L) can mediate the proteolytic cleavage of intracellular PGRN into poly-granulin and granulin fragments. Further, PGRN and Cat L co-localize in lysosomes of HEK293 cells, iPSC-derived neurons and human cortical neurons from human postmortem tissue. These data identify Cat L as a key intracellular lysosomal PGRN protease, and provides an intriguing new link between lysosomal dysfunction and FTLD."xsd:string |
| http://purl.uniprot.org/citations/28743268 | http://purl.org/dc/terms/identifier | "doi:10.1186/s13024-017-0196-6"xsd:string |
| http://purl.uniprot.org/citations/28743268 | http://purl.org/dc/terms/identifier | "doi:10.1186/s13024-017-0196-6"xsd:string |
| http://purl.uniprot.org/citations/28743268 | http://purl.uniprot.org/core/author | "Lam Y.W."xsd:string |
| http://purl.uniprot.org/citations/28743268 | http://purl.uniprot.org/core/author | "Lam Y.W."xsd:string |
| http://purl.uniprot.org/citations/28743268 | http://purl.uniprot.org/core/author | "Bogyo M."xsd:string |
| http://purl.uniprot.org/citations/28743268 | http://purl.uniprot.org/core/author | "Bogyo M."xsd:string |
| http://purl.uniprot.org/citations/28743268 | http://purl.uniprot.org/core/author | "Dickson D.W."xsd:string |
| http://purl.uniprot.org/citations/28743268 | http://purl.uniprot.org/core/author | "Dickson D.W."xsd:string |
| http://purl.uniprot.org/citations/28743268 | http://purl.uniprot.org/core/author | "Prudencio M."xsd:string |
| http://purl.uniprot.org/citations/28743268 | http://purl.uniprot.org/core/author | "Prudencio M."xsd:string |
| http://purl.uniprot.org/citations/28743268 | http://purl.uniprot.org/core/author | "Lau K.F."xsd:string |
| http://purl.uniprot.org/citations/28743268 | http://purl.uniprot.org/core/author | "Lau K.F."xsd:string |
| http://purl.uniprot.org/citations/28743268 | http://purl.uniprot.org/core/author | "Lee C.W."xsd:string |
| http://purl.uniprot.org/citations/28743268 | http://purl.uniprot.org/core/author | "Lee C.W."xsd:string |
| http://purl.uniprot.org/citations/28743268 | http://purl.uniprot.org/core/author | "Petrucelli L."xsd:string |
| http://purl.uniprot.org/citations/28743268 | http://purl.uniprot.org/core/author | "Petrucelli L."xsd:string |
| http://purl.uniprot.org/citations/28743268 | http://purl.uniprot.org/core/author | "Gao F.B."xsd:string |
| http://purl.uniprot.org/citations/28743268 | http://purl.uniprot.org/core/author | "Gao F.B."xsd:string |
| http://purl.uniprot.org/citations/28743268 | http://purl.uniprot.org/core/author | "Carlomagno Y."xsd:string |
| http://purl.uniprot.org/citations/28743268 | http://purl.uniprot.org/core/author | "Carlomagno Y."xsd:string |
| http://purl.uniprot.org/citations/28743268 | http://purl.uniprot.org/core/author | "Almeida S."xsd:string |
| http://purl.uniprot.org/citations/28743268 | http://purl.uniprot.org/core/author | "Almeida S."xsd:string |