| http://purl.uniprot.org/citations/28751190 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28751190 | http://www.w3.org/2000/01/rdf-schema#comment | "Septins are a family of filament-forming GTP-binding proteins that serve as scaffolds and diffusion barriers in various cellular processes. Septin 6 is known as a fusion partner of mixed-lineage leukemia in infant acute myeloid leukemia. The occurrence of the fusion gene is associated with a reduced expression of septin 6 itself. The role of septin 6 in hematopoiesis and whether it is involved in scaffolds within hematopoietic cells is not known. Septin 6-deficient hematopoietic stem cells (HSCs) present with an increased engraftment potential but altered lymphoid differentiation with a reduced contribution to the T-cell compartment and an increased B-cell contribution. Although multipotent progenitor cells showed a very distinct septin 6 filament organization and intracellular distribution, their function was not impaired by septin 6 deficiency. Our data therefore suggest a regulatory role for septin 6 in long-term HSC function and lymphoid lineage differentiation."xsd:string |
| http://purl.uniprot.org/citations/28751190 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.exphem.2017.07.005"xsd:string |
| http://purl.uniprot.org/citations/28751190 | http://purl.uniprot.org/core/author | "Geiger H."xsd:string |
| http://purl.uniprot.org/citations/28751190 | http://purl.uniprot.org/core/author | "Sakk V."xsd:string |
| http://purl.uniprot.org/citations/28751190 | http://purl.uniprot.org/core/author | "Senger K."xsd:string |
| http://purl.uniprot.org/citations/28751190 | http://purl.uniprot.org/core/author | "Florian M.C."xsd:string |
| http://purl.uniprot.org/citations/28751190 | http://purl.uniprot.org/core/author | "Marka G."xsd:string |
| http://purl.uniprot.org/citations/28751190 | http://purl.uniprot.org/core/author | "Soller K."xsd:string |
| http://purl.uniprot.org/citations/28751190 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28751190 | http://purl.uniprot.org/core/name | "Exp Hematol"xsd:string |
| http://purl.uniprot.org/citations/28751190 | http://purl.uniprot.org/core/pages | "45-55"xsd:string |
| http://purl.uniprot.org/citations/28751190 | http://purl.uniprot.org/core/title | "Septin 6 regulates engraftment and lymphoid differentiation potential of murine long-term hematopoietic stem cells."xsd:string |
| http://purl.uniprot.org/citations/28751190 | http://purl.uniprot.org/core/volume | "55"xsd:string |
| http://purl.uniprot.org/citations/28751190 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28751190 |
| http://purl.uniprot.org/citations/28751190 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28751190 |
| http://purl.uniprot.org/uniprot/#_A2A3W1-mappedCitation-28751190 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28751190 |
| http://purl.uniprot.org/uniprot/#_Q3UUU4-mappedCitation-28751190 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28751190 |
| http://purl.uniprot.org/uniprot/#_Q9R1T4-mappedCitation-28751190 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28751190 |
| http://purl.uniprot.org/uniprot/A2A3W1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28751190 |
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| http://purl.uniprot.org/uniprot/Q3UUU4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28751190 |