| http://purl.uniprot.org/citations/28751426 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28751426 | http://www.w3.org/2000/01/rdf-schema#comment | "Excessive or persistent inflammation and hepatocyte death are the key triggers of liver diseases. The poly(ADP-ribose) polymerase (PARP) proteins induce cell death and inflammation. Chemical inhibition of PARP activity protects against liver injury during concanavalin A (ConA)-induced hepatitis. In this mice model, ConA activates immune cells, which promote inflammation and induce hepatocyte death, mediated by the activated invariant natural killer T (iNKT) lymphocyte population. We analyzed immune cell populations in the liver and several lymphoid organs, such as the spleen, thymus, and bone marrow in Parp2-deficient mice to better define the role of PARP proteins in liver immunity and inflammation at steady state and during ConA-induced hepatitis. We show that 1) the genetic inactivation of Parp2, but not Parp1, protected mice from ConA hepatitis without deregulating cytokine expression and leucocyte recruitment; 2) cellularity was lower in the thymus, but not in spleen, liver, or bone marrow of Parp2-/- mice; 3) spleen and liver iNKT lymphocytes, as well as thymic T and NKT lymphocytes were reduced in Parp2 knockout mice. In conclusion, our results suggest that the defect of T-lymphocyte maturation in Parp2 knockout mice leads to a systemic reduction of iNKT cells, reducing hepatocyte death during ConA-mediated liver damage, thus protecting the mice from hepatitis.NEW & NOTEWORTHY The genetic inactivation of Parp2, but not Parp1, protects mice from concanavalin A hepatitis. Immune cell populations are lower in the thymus, but not in the spleen, liver, or bone marrow of Parp2-deficient mice compared with wild-type mice. Spleen and liver invariant natural killer T (NKT) lymphocytes, as well as thymic T and NKT lymphocytes, are reduced in Parp2-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/28751426 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpgi.00436.2016"xsd:string |
| http://purl.uniprot.org/citations/28751426 | http://purl.uniprot.org/core/author | "Samson M."xsd:string |
| http://purl.uniprot.org/citations/28751426 | http://purl.uniprot.org/core/author | "Dantzer F."xsd:string |
| http://purl.uniprot.org/citations/28751426 | http://purl.uniprot.org/core/author | "Piquet-Pellorce C."xsd:string |
| http://purl.uniprot.org/citations/28751426 | http://purl.uniprot.org/core/author | "Dion S."xsd:string |
| http://purl.uniprot.org/citations/28751426 | http://purl.uniprot.org/core/author | "Lucas-Clerc C."xsd:string |
| http://purl.uniprot.org/citations/28751426 | http://purl.uniprot.org/core/author | "Genet V."xsd:string |
| http://purl.uniprot.org/citations/28751426 | http://purl.uniprot.org/core/author | "Filliol A."xsd:string |
| http://purl.uniprot.org/citations/28751426 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28751426 | http://purl.uniprot.org/core/name | "Am J Physiol Gastrointest Liver Physiol"xsd:string |
| http://purl.uniprot.org/citations/28751426 | http://purl.uniprot.org/core/pages | "G399-G409"xsd:string |
| http://purl.uniprot.org/citations/28751426 | http://purl.uniprot.org/core/title | "PARP2 deficiency affects invariant-NKT-cell maturation and protects mice from concanavalin A-induced liver injury."xsd:string |
| http://purl.uniprot.org/citations/28751426 | http://purl.uniprot.org/core/volume | "313"xsd:string |
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