| http://purl.uniprot.org/citations/28751771 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28751771 | http://www.w3.org/2000/01/rdf-schema#comment | "RUNX1-mutated acute myeloid leukemia (AML) show a distinct pattern of genetic abnormalities and an adverse prognosis. We analyzed the impact of multiple RUNX1 mutations and RUNX1 wild-type (WT) loss in 467 AML with RUNX1 mutations (mut): (1) RUNX1 WT loss (n=53), (2) >1 RUNX1mut (n=94) and (3) 1 RUNX1mut (n=323). In 1 RUNX1mut, +8 was most frequent, whereas in WT loss +13 was the most abundant trisomy (+8: 66% vs 31%, P=0.022; +13: 15% vs 62%, P<0.001). Analyses of 28 genes in 163 selected cases revealed SRSF2 (39%), ASXL1 (36%), DNMT3A (19%), IDH2 (17%) and SF3B1 (17%) as most frequently mutated genes. RUNX1 WT loss showed a higher frequency of ASXL1mut compared with the other cases (50% vs 29%, P=0.009). Median overall survival (OS) in the total cohort was 14 months. WT loss (OS: 5 months) and >1 RUNX1mut (14 months) showed an adverse impact on prognosis compared with 1 RUNX1mut (22 months; P=0.002 and 0.048, respectively). Mutations in ASXL1 and ⩾2 additional mutations correlated with shorter OS (10 vs 18 months, P=0.028; 12 vs 20 months, P=0.017). Thus, the number of RUNX1mut, RUNX1 WT loss and the number and type of additional mutations is biologically and clinically relevant."xsd:string |
| http://purl.uniprot.org/citations/28751771 | http://purl.org/dc/terms/identifier | "doi:10.1038/leu.2017.239"xsd:string |
| http://purl.uniprot.org/citations/28751771 | http://purl.uniprot.org/core/author | "Stengel A."xsd:string |
| http://purl.uniprot.org/citations/28751771 | http://purl.uniprot.org/core/author | "Haferlach T."xsd:string |
| http://purl.uniprot.org/citations/28751771 | http://purl.uniprot.org/core/author | "Kern W."xsd:string |
| http://purl.uniprot.org/citations/28751771 | http://purl.uniprot.org/core/author | "Haferlach C."xsd:string |
| http://purl.uniprot.org/citations/28751771 | http://purl.uniprot.org/core/author | "Meggendorfer M."xsd:string |
| http://purl.uniprot.org/citations/28751771 | http://purl.uniprot.org/core/author | "Nadarajah N."xsd:string |
| http://purl.uniprot.org/citations/28751771 | http://purl.uniprot.org/core/author | "Perglerova K."xsd:string |
| http://purl.uniprot.org/citations/28751771 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/28751771 | http://purl.uniprot.org/core/name | "Leukemia"xsd:string |
| http://purl.uniprot.org/citations/28751771 | http://purl.uniprot.org/core/pages | "295-302"xsd:string |
| http://purl.uniprot.org/citations/28751771 | http://purl.uniprot.org/core/title | "Number of RUNX1 mutations, wild-type allele loss and additional mutations impact on prognosis in adult RUNX1-mutated AML."xsd:string |
| http://purl.uniprot.org/citations/28751771 | http://purl.uniprot.org/core/volume | "32"xsd:string |
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