| http://purl.uniprot.org/citations/28754897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28754897 | http://www.w3.org/2000/01/rdf-schema#comment | "Toll-like receptor 2 (TLR2) mediates the innate immune response to bacterial lipopeptides and peptidoglycans by stimulating the production of inflammatory cytokines. However, the mechanisms by which TLR2 signaling regulates type I interferon (IFN)-β production are poorly understood. Here, we identified Src homology 2-containing protein tyrosine phosphatase 2 (SHP2) as a negative regulator of TLR2-induced IFN-β production. Pharmacological inhibition or reduced expression of SHP2 potentiated TLR2 agonist-mediated IFN-β transcription and STAT1 activation, whereas overexpression of SHP2 impaired IFN-β transcription and STAT1 activation. SHP2 physically associated with the glycogen synthase kinase 3β (Gsk3β) in an agonist-dependent manner. Gsk3β positively regulates transcription of IFN-β following TLR2 stimulation by inhibiting the phosphorylation of SHP2. SHP2 inhibited the transcriptional activity of IRF-1 and IRF-8 at the IFN-β promoter. Remarkably, IRF-1 and IRF-8 are recruited to the IFN-β promoter in a SHP2 phosphatase activity-dependent manner. These findings provide insight into the mechanisms by which SHP2 and Gsk3β work together to modulate TLR2-mediated IFN-β production in macrophages."xsd:string |
| http://purl.uniprot.org/citations/28754897 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-017-07316-3"xsd:string |
| http://purl.uniprot.org/citations/28754897 | http://purl.uniprot.org/core/author | "Lee S.Y."xsd:string |
| http://purl.uniprot.org/citations/28754897 | http://purl.uniprot.org/core/author | "Park J.H."xsd:string |
| http://purl.uniprot.org/citations/28754897 | http://purl.uniprot.org/core/author | "Ko R."xsd:string |
| http://purl.uniprot.org/citations/28754897 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28754897 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/28754897 | http://purl.uniprot.org/core/pages | "6807"xsd:string |
| http://purl.uniprot.org/citations/28754897 | http://purl.uniprot.org/core/title | "Reciprocal regulation of TLR2-mediated IFN-beta production by SHP2 and Gsk3beta."xsd:string |
| http://purl.uniprot.org/citations/28754897 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/28754897 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28754897 |
| http://purl.uniprot.org/citations/28754897 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28754897 |
| http://purl.uniprot.org/uniprot/#_E9QAQ5-mappedCitation-28754897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28754897 |
| http://purl.uniprot.org/uniprot/#_Q63848-mappedCitation-28754897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28754897 |
| http://purl.uniprot.org/uniprot/#_Q05C78-mappedCitation-28754897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28754897 |
| http://purl.uniprot.org/uniprot/#_Q06124-mappedCitation-28754897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28754897 |
| http://purl.uniprot.org/uniprot/#_P35235-mappedCitation-28754897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28754897 |
| http://purl.uniprot.org/uniprot/#_Q3TB31-mappedCitation-28754897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28754897 |
| http://purl.uniprot.org/uniprot/#_Q5KU03-mappedCitation-28754897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28754897 |
| http://purl.uniprot.org/uniprot/#_Q9CT18-mappedCitation-28754897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28754897 |
| http://purl.uniprot.org/uniprot/#_Q9WV60-mappedCitation-28754897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28754897 |
| http://purl.uniprot.org/uniprot/Q9CT18 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28754897 |
| http://purl.uniprot.org/uniprot/P35235 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28754897 |
| http://purl.uniprot.org/uniprot/Q63848 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28754897 |