| http://purl.uniprot.org/citations/28760339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28760339 | http://www.w3.org/2000/01/rdf-schema#comment | "Ran-binding protein 3 (RanBP3) is a primarily nuclear Ran-binding protein that functions as an accessory factor in the Ran GTPase system. RanBP3 associates with Ran-specific nucleotide exchange factor RCC1 and enhances its catalytic activity towards Ran. RanBP3 also promotes CRM1-mediated nuclear export as well as CRM1-independent nuclear export of β-catenin, Smad2, and Smad3. Nuclear import of RanBP3 is dependent on the nuclear import adaptor protein importin-α and, RanBP3 is imported more efficiently by importin-α3 than by other members of the importin-α family. Protein kinase signaling pathways control nucleocytoplasmic transport through phosphorylation of RanBP3 at Ser58, immediately C-terminal to the nuclear localization signal (NLS) in the N-terminal region of RanBP3. Here we report the crystal structure of human importin-α3 bound to an N-terminal fragment of human RanBP3 containing the NLS sequence that is necessary and sufficient for nuclear import. The structure reveals that RanBP3 binds to importin-α3 residues that are strictly conserved in all seven isoforms of human importin-α at the major NLS-binding site, indicating that the region of importin-α outside the NLS-binding site, possibly the autoinhibotory importin-β1-binding domain, may be the key determinant for the preferential binding of RanBP3 to importin-α3. Computational docking simulation indicates that phosphorylation of RanBP3 at Ser58 could potentially stabilize the association of RanBP3 with importin-α through interactions between the phosphate moiety of phospho-Ser58 of RanBP3 and a cluster of basic residues (Arg96 and Lys97 in importin-α3) on armadillo repeat 1 of importin-α."xsd:string |
| http://purl.uniprot.org/citations/28760339 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2017.07.155"xsd:string |
| http://purl.uniprot.org/citations/28760339 | http://purl.uniprot.org/core/author | "Matsuura Y."xsd:string |
| http://purl.uniprot.org/citations/28760339 | http://purl.uniprot.org/core/author | "Koyama M."xsd:string |
| http://purl.uniprot.org/citations/28760339 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28760339 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/28760339 | http://purl.uniprot.org/core/pages | "609-613"xsd:string |
| http://purl.uniprot.org/citations/28760339 | http://purl.uniprot.org/core/title | "Crystal structure of importin-alpha3 bound to the nuclear localization signal of Ran-binding protein 3."xsd:string |
| http://purl.uniprot.org/citations/28760339 | http://purl.uniprot.org/core/volume | "491"xsd:string |
| http://purl.uniprot.org/citations/28760339 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28760339 |
| http://purl.uniprot.org/citations/28760339 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28760339 |
| http://purl.uniprot.org/uniprot/#_O00629-mappedCitation-28760339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28760339 |
| http://purl.uniprot.org/uniprot/#_Q9H6Z4-mappedCitation-28760339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28760339 |
| http://purl.uniprot.org/uniprot/O00629 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28760339 |
| http://purl.uniprot.org/uniprot/Q9H6Z4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28760339 |