| http://purl.uniprot.org/citations/28763438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28763438 | http://www.w3.org/2000/01/rdf-schema#comment | "Enhancing brown fat activity and promoting white fat browning are attractive therapeutic strategies for treating obesity and associated metabolic disorders. To provide a comprehensive picture of the gene regulatory network in these processes, we conducted a series of transcriptome studies by RNA sequencing (RNA-seq) and quantified the mRNA and long noncoding RNA (lncRNA) changes during white fat browning (chronic cold exposure, beta-adrenergic agonist treatment, and intense exercise) and brown fat activation or inactivation (acute cold exposure or thermoneutrality, respectively). mRNA-lncRNA coexpression networks revealed dynamically regulated lncRNAs to be largely embedded in nutrient and energy metabolism pathways. We identified a brown adipose tissue-enriched lncRNA, lncBATE10, that was governed by the cAMP-cAMP response element-binding protein (Creb) axis and required for a full brown fat differentiation and white fat browning program. Mechanistically, lncBATE10 can decoy Celf1 from Pgc1α, thereby protecting Pgc1α mRNA from repression by Celf1. Together, these studies provide a comprehensive data framework to interrogate the transcriptomic changes accompanying energy homeostasis transition in adipose tissue."xsd:string |
| http://purl.uniprot.org/citations/28763438 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pbio.2002176"xsd:string |
| http://purl.uniprot.org/citations/28763438 | http://purl.uniprot.org/core/author | "Chen P."xsd:string |
| http://purl.uniprot.org/citations/28763438 | http://purl.uniprot.org/core/author | "Ghosh S."xsd:string |
| http://purl.uniprot.org/citations/28763438 | http://purl.uniprot.org/core/author | "Kim H.J."xsd:string |
| http://purl.uniprot.org/citations/28763438 | http://purl.uniprot.org/core/author | "Xu D."xsd:string |
| http://purl.uniprot.org/citations/28763438 | http://purl.uniprot.org/core/author | "Sun L."xsd:string |
| http://purl.uniprot.org/citations/28763438 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/28763438 | http://purl.uniprot.org/core/author | "Bai Z."xsd:string |
| http://purl.uniprot.org/citations/28763438 | http://purl.uniprot.org/core/author | "Yoon M.J."xsd:string |
| http://purl.uniprot.org/citations/28763438 | http://purl.uniprot.org/core/author | "Zhang Z.C."xsd:string |
| http://purl.uniprot.org/citations/28763438 | http://purl.uniprot.org/core/author | "Xu S.H."xsd:string |
| http://purl.uniprot.org/citations/28763438 | http://purl.uniprot.org/core/author | "Chia S.Y."xsd:string |
| http://purl.uniprot.org/citations/28763438 | http://purl.uniprot.org/core/author | "Lo K.A."xsd:string |
| http://purl.uniprot.org/citations/28763438 | http://purl.uniprot.org/core/author | "Chai X.R."xsd:string |
| http://purl.uniprot.org/citations/28763438 | http://purl.uniprot.org/core/author | "Siang D.T.C."xsd:string |
| http://purl.uniprot.org/citations/28763438 | http://purl.uniprot.org/core/author | "Walet A.C.E."xsd:string |
| http://purl.uniprot.org/citations/28763438 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28763438 | http://purl.uniprot.org/core/name | "PLoS Biol"xsd:string |
| http://purl.uniprot.org/citations/28763438 | http://purl.uniprot.org/core/pages | "e2002176"xsd:string |
| http://purl.uniprot.org/citations/28763438 | http://purl.uniprot.org/core/title | "Dynamic transcriptome changes during adipose tissue energy expenditure reveal critical roles for long noncoding RNA regulators."xsd:string |
| http://purl.uniprot.org/citations/28763438 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/28763438 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28763438 |
| http://purl.uniprot.org/citations/28763438 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28763438 |