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http://purl.uniprot.org/citations/28766587http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/28766587http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/28766587http://www.w3.org/2000/01/rdf-schema#comment"The non-hydrolyzable S-linked azasugars, 1,6-α-mannosylthio- and 1,6-α-mannobiosylthioisofagomine, were synthesized and shown to bind with high affinity to a family 76 endo-1,6-α-mannanase from Bacillus circulans. X-ray crystallography showed an atypical interaction of the isofagomine nitrogen with the catalytic acid/base. Molecular dynamics simulations reveal that the atypical binding results from sulfur perturbing the most stable form away from the nucleophile interaction preferred for the O-linked congener."xsd:string
http://purl.uniprot.org/citations/28766587http://purl.org/dc/terms/identifier"doi:10.1039/c7cc04977c"xsd:string
http://purl.uniprot.org/citations/28766587http://purl.org/dc/terms/identifier"doi:10.1039/c7cc04977c"xsd:string
http://purl.uniprot.org/citations/28766587http://purl.uniprot.org/core/author"Davies G.J."xsd:string
http://purl.uniprot.org/citations/28766587http://purl.uniprot.org/core/author"Davies G.J."xsd:string
http://purl.uniprot.org/citations/28766587http://purl.uniprot.org/core/author"Jin Y."xsd:string
http://purl.uniprot.org/citations/28766587http://purl.uniprot.org/core/author"Jin Y."xsd:string
http://purl.uniprot.org/citations/28766587http://purl.uniprot.org/core/author"Williams S.J."xsd:string
http://purl.uniprot.org/citations/28766587http://purl.uniprot.org/core/author"Williams S.J."xsd:string
http://purl.uniprot.org/citations/28766587http://purl.uniprot.org/core/author"Rovira C."xsd:string
http://purl.uniprot.org/citations/28766587http://purl.uniprot.org/core/author"Rovira C."xsd:string
http://purl.uniprot.org/citations/28766587http://purl.uniprot.org/core/author"Coines J."xsd:string
http://purl.uniprot.org/citations/28766587http://purl.uniprot.org/core/author"Coines J."xsd:string
http://purl.uniprot.org/citations/28766587http://purl.uniprot.org/core/author"Belz T."xsd:string
http://purl.uniprot.org/citations/28766587http://purl.uniprot.org/core/author"Belz T."xsd:string
http://purl.uniprot.org/citations/28766587http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/28766587http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/28766587http://purl.uniprot.org/core/name"Chem. Commun. (Camb.)"xsd:string
http://purl.uniprot.org/citations/28766587http://purl.uniprot.org/core/name"Chem Commun (Camb)"xsd:string
http://purl.uniprot.org/citations/28766587http://purl.uniprot.org/core/pages"9238-9241"xsd:string
http://purl.uniprot.org/citations/28766587http://purl.uniprot.org/core/pages"9238-9241"xsd:string
http://purl.uniprot.org/citations/28766587http://purl.uniprot.org/core/title"An atypical interaction explains the high-affinity of a non-hydrolyzable S-linked 1,6-alpha-mannanase inhibitor."xsd:string
http://purl.uniprot.org/citations/28766587http://purl.uniprot.org/core/title"An atypical interaction explains the high-affinity of a non-hydrolyzable S-linked 1,6-alpha-mannanase inhibitor."xsd:string