| http://purl.uniprot.org/citations/28767037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28767037 | http://www.w3.org/2000/01/rdf-schema#comment | "Coactivator complexes SAGA and NuA4 stimulate transcription by post-translationally modifying chromatin. Both complexes contain the Tra1 subunit, a highly conserved 3744-residue protein from the Phosphoinositide 3-Kinase-related kinase (PIKK) family and a direct target for multiple sequence-specific activators. We present the Cryo-EM structure of Saccharomyces cerevsisae Tra1 to 3.7 Å resolution, revealing an extensive network of alpha-helical solenoids organized into a diamond ring conformation and is strikingly reminiscent of DNA-PKcs, suggesting a direct role for Tra1 in DNA repair. The structure was fitted into an existing SAGA EM reconstruction and reveals limited contact surfaces to Tra1, hence it does not act as a molecular scaffold within SAGA. Mutations that affect activator targeting are distributed across the Tra1 structure, but also cluster within the N-terminal Finger region, indicating the presence of an activator interaction site. The structure of Tra1 is a key milestone in deciphering the mechanism of multiple coactivator complexes."xsd:string |
| http://purl.uniprot.org/citations/28767037 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.28384"xsd:string |
| http://purl.uniprot.org/citations/28767037 | http://purl.uniprot.org/core/author | "Diaz-Santin L.M."xsd:string |
| http://purl.uniprot.org/citations/28767037 | http://purl.uniprot.org/core/author | "Lukoyanova N."xsd:string |
| http://purl.uniprot.org/citations/28767037 | http://purl.uniprot.org/core/author | "Cheung A.C."xsd:string |
| http://purl.uniprot.org/citations/28767037 | http://purl.uniprot.org/core/author | "Aciyan E."xsd:string |
| http://purl.uniprot.org/citations/28767037 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28767037 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/28767037 | http://purl.uniprot.org/core/pages | "e28384"xsd:string |
| http://purl.uniprot.org/citations/28767037 | http://purl.uniprot.org/core/title | "Cryo-EM structure of the SAGA and NuA4 coactivator subunit Tra1 at 3.7 angstrom resolution."xsd:string |
| http://purl.uniprot.org/citations/28767037 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/28767037 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28767037 |
| http://purl.uniprot.org/citations/28767037 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28767037 |
| http://purl.uniprot.org/uniprot/#_A0A8H4F9W4-mappedCitation-28767037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28767037 |
| http://purl.uniprot.org/uniprot/#_P38811-mappedCitation-28767037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28767037 |
| http://purl.uniprot.org/uniprot/A0A8H4F9W4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28767037 |
| http://purl.uniprot.org/uniprot/P38811 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28767037 |