| http://purl.uniprot.org/citations/28768895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28768895 | http://www.w3.org/2000/01/rdf-schema#comment | "Constitutive p16Ink4a expression, along with senescence-associated β-galactosidase (SAβG), are commonly accepted biomarkers of senescent cells (SCs). Recent reports attributed improvement of the healthspan of aged mice following p16Ink4a-positive cell killing to the eradication of accumulated SCs. However, detection of p16Ink4a/SAβG-positive macrophages in the adipose tissue of old mice and in the peritoneal cavity of young animals following injection of alginate-encapsulated SCs has raised concerns about the exclusivity of these markers for SCs. Here we report that expression of p16Ink4a and SAβG in macrophages is acquired as part of a physiological response to immune stimuli rather than through senescence, consistent with reports that p16Ink4a plays a role in macrophage polarization and response. Unlike SCs, p16Ink4a/SAβG-positive macrophages can be induced in p53-null mice. Macrophages, but not mesenchymal SCs, lose both markers in response to M1-[LPS, IFN-α, Poly(I:C)] and increase their expression in response to M2-inducing stimuli (IL-4, IL-13). Moreover, interferon-inducing agent Poly(I:C) dramatically reduced p16Ink4a expression in vivo in our alginate bead model and in the adipose tissue of aged mice. These observations suggest that the antiaging effects following eradication of p16Ink4a-positive cells may not be solely attributed to SCs but also to non-senescent p16Ink4a/SAβG-positive macrophages."xsd:string |
| http://purl.uniprot.org/citations/28768895 | http://purl.org/dc/terms/identifier | "doi:10.18632/aging.101268"xsd:string |
| http://purl.uniprot.org/citations/28768895 | http://purl.uniprot.org/core/author | "Rydkina E."xsd:string |
| http://purl.uniprot.org/citations/28768895 | http://purl.uniprot.org/core/author | "Gudkov A.V."xsd:string |
| http://purl.uniprot.org/citations/28768895 | http://purl.uniprot.org/core/author | "Hall B.M."xsd:string |
| http://purl.uniprot.org/citations/28768895 | http://purl.uniprot.org/core/author | "Gitlin I.I."xsd:string |
| http://purl.uniprot.org/citations/28768895 | http://purl.uniprot.org/core/author | "Gleiberman A.S."xsd:string |
| http://purl.uniprot.org/citations/28768895 | http://purl.uniprot.org/core/author | "Vujcic S."xsd:string |
| http://purl.uniprot.org/citations/28768895 | http://purl.uniprot.org/core/author | "Krasnov P."xsd:string |
| http://purl.uniprot.org/citations/28768895 | http://purl.uniprot.org/core/author | "Gollnick S.O."xsd:string |
| http://purl.uniprot.org/citations/28768895 | http://purl.uniprot.org/core/author | "Chernova O.B."xsd:string |
| http://purl.uniprot.org/citations/28768895 | http://purl.uniprot.org/core/author | "Balan V."xsd:string |
| http://purl.uniprot.org/citations/28768895 | http://purl.uniprot.org/core/author | "Balan K."xsd:string |
| http://purl.uniprot.org/citations/28768895 | http://purl.uniprot.org/core/author | "Leonova K.I."xsd:string |
| http://purl.uniprot.org/citations/28768895 | http://purl.uniprot.org/core/author | "Strom E."xsd:string |
| http://purl.uniprot.org/citations/28768895 | http://purl.uniprot.org/core/author | "Virtuoso L.P."xsd:string |
| http://purl.uniprot.org/citations/28768895 | http://purl.uniprot.org/core/author | "Consiglio C.R."xsd:string |
| http://purl.uniprot.org/citations/28768895 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28768895 | http://purl.uniprot.org/core/name | "Aging (Albany NY)"xsd:string |
| http://purl.uniprot.org/citations/28768895 | http://purl.uniprot.org/core/pages | "1867-1884"xsd:string |
| http://purl.uniprot.org/citations/28768895 | http://purl.uniprot.org/core/title | "p16(Ink4a) and senescence-associated beta-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli."xsd:string |
| http://purl.uniprot.org/citations/28768895 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/28768895 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28768895 |
| http://purl.uniprot.org/citations/28768895 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28768895 |