| http://purl.uniprot.org/citations/28772263 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28772263 | http://www.w3.org/2000/01/rdf-schema#comment | "In this paper, we report previously unknown roles for collectin-11 (CL-11, a soluble C-type lectin) in modulating the retinal pigment epithelial (RPE) cell functions of phagocytosis and cytokine production. We found that CL-11 and its carbohydrate ligand are expressed in both the murine and human neural retina; these resemble each other in terms of RPE and photoreceptor cells. Functional analysis of murine RPE cells showed that CL-11 facilitates the opsonophagocytosis of photoreceptor outer segments and apoptotic cells, and also upregulates IL-10 production. Mechanistic analysis revealed that calreticulin on the RPE cells is required for CL-11-mediated opsonophagocytosis whereas signal-regulatory protein α and mannosyl residues on the cells are involved in the CL-11-mediated upregulation of IL-10 production. This study is the first to demonstrate the role of CL-11 and the molecular mechanisms involved in modulating RPE cell phagocytosis and cytokine production. It provides a new insight into retinal health and disease and has implications for other phagocytic cells."xsd:string |
| http://purl.uniprot.org/citations/28772263 | http://purl.org/dc/terms/identifier | "doi:10.1159/000478042"xsd:string |
| http://purl.uniprot.org/citations/28772263 | http://purl.uniprot.org/core/author | "Dong X."xsd:string |
| http://purl.uniprot.org/citations/28772263 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/28772263 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/28772263 | http://purl.uniprot.org/core/author | "Li K."xsd:string |
| http://purl.uniprot.org/citations/28772263 | http://purl.uniprot.org/core/author | "Ma L."xsd:string |
| http://purl.uniprot.org/citations/28772263 | http://purl.uniprot.org/core/author | "Xu H."xsd:string |
| http://purl.uniprot.org/citations/28772263 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/28772263 | http://purl.uniprot.org/core/author | "Zhou W."xsd:string |
| http://purl.uniprot.org/citations/28772263 | http://purl.uniprot.org/core/author | "Wu W."xsd:string |
| http://purl.uniprot.org/citations/28772263 | http://purl.uniprot.org/core/author | "Nandrot E.F."xsd:string |
| http://purl.uniprot.org/citations/28772263 | http://purl.uniprot.org/core/author | "Bhuckory M.B."xsd:string |
| http://purl.uniprot.org/citations/28772263 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28772263 | http://purl.uniprot.org/core/name | "J Innate Immun"xsd:string |
| http://purl.uniprot.org/citations/28772263 | http://purl.uniprot.org/core/pages | "529-545"xsd:string |
| http://purl.uniprot.org/citations/28772263 | http://purl.uniprot.org/core/title | "Collectin-11 Is an Important Modulator of Retinal Pigment Epithelial Cell Phagocytosis and Cytokine Production."xsd:string |
| http://purl.uniprot.org/citations/28772263 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/28772263 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28772263 |
| http://purl.uniprot.org/citations/28772263 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28772263 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0M6-mappedCitation-28772263 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28772263 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VKG6-mappedCitation-28772263 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28772263 |
| http://purl.uniprot.org/uniprot/#_Q3SXB8-mappedCitation-28772263 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28772263 |
| http://purl.uniprot.org/uniprot/#_Q9BWP8-mappedCitation-28772263 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28772263 |