| http://purl.uniprot.org/citations/28774900 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28774900 | http://www.w3.org/2000/01/rdf-schema#comment | "During terminal differentiation, the global protein complement is remodeled, as epitomized by erythrocytes, whose cytosol is ~98% globin. The erythroid proteome undergoes a rapid transition at the reticulocyte stage; however, the mechanisms driving programmed elimination of preexisting cytosolic proteins are unclear. We found that a mutation in the murine Ube2o gene, which encodes a ubiquitin-conjugating enzyme induced during erythropoiesis, results in anemia. Proteomic analysis suggested that UBE2O is a broad-spectrum ubiquitinating enzyme that remodels the erythroid proteome. In particular, ribosome elimination, a hallmark of reticulocyte differentiation, was defective in Ube2o-/- mutants. UBE2O recognized ribosomal proteins and other substrates directly, targeting them to proteasomes for degradation. Thus, in reticulocytes, the induction of ubiquitinating factors may drive the transition from a complex to a simple proteome."xsd:string |
| http://purl.uniprot.org/citations/28774900 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aan0218"xsd:string |
| http://purl.uniprot.org/citations/28774900 | http://purl.uniprot.org/core/author | "Finley D."xsd:string |
| http://purl.uniprot.org/citations/28774900 | http://purl.uniprot.org/core/author | "Gygi S.P."xsd:string |
| http://purl.uniprot.org/citations/28774900 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/28774900 | http://purl.uniprot.org/core/author | "Tian G."xsd:string |
| http://purl.uniprot.org/citations/28774900 | http://purl.uniprot.org/core/author | "Yao Y."xsd:string |
| http://purl.uniprot.org/citations/28774900 | http://purl.uniprot.org/core/author | "Fleming M.D."xsd:string |
| http://purl.uniprot.org/citations/28774900 | http://purl.uniprot.org/core/author | "Wilson-Grady J.T."xsd:string |
| http://purl.uniprot.org/citations/28774900 | http://purl.uniprot.org/core/author | "Campagna D.R."xsd:string |
| http://purl.uniprot.org/citations/28774900 | http://purl.uniprot.org/core/author | "Weiss M.J."xsd:string |
| http://purl.uniprot.org/citations/28774900 | http://purl.uniprot.org/core/author | "Schmidt P.J."xsd:string |
| http://purl.uniprot.org/citations/28774900 | http://purl.uniprot.org/core/author | "Justice M.J."xsd:string |
| http://purl.uniprot.org/citations/28774900 | http://purl.uniprot.org/core/author | "Nguyen A.T."xsd:string |
| http://purl.uniprot.org/citations/28774900 | http://purl.uniprot.org/core/author | "Paulo J.A."xsd:string |
| http://purl.uniprot.org/citations/28774900 | http://purl.uniprot.org/core/author | "Prado M.A."xsd:string |
| http://purl.uniprot.org/citations/28774900 | http://purl.uniprot.org/core/author | "Sendamarai A.K."xsd:string |
| http://purl.uniprot.org/citations/28774900 | http://purl.uniprot.org/core/author | "Min M."xsd:string |
| http://purl.uniprot.org/citations/28774900 | http://purl.uniprot.org/core/author | "Dederer V."xsd:string |
| http://purl.uniprot.org/citations/28774900 | http://purl.uniprot.org/core/author | "Kawan M."xsd:string |
| http://purl.uniprot.org/citations/28774900 | http://purl.uniprot.org/core/author | "Kuehnle N."xsd:string |
| http://purl.uniprot.org/citations/28774900 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28774900 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/28774900 | http://purl.uniprot.org/core/pages | "eaan0218"xsd:string |