| http://purl.uniprot.org/citations/28776731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28776731 | http://www.w3.org/2000/01/rdf-schema#comment | "Graves' disease is an autoimmune process in which the thyroid gland is triggered by autoantibodies, resulting in hyperthyroidism. The purpose of the present study is to elucidate whether exon-1 49 A/G and promoter region 318C/T polymorphisms in the CTLA-4 gene. This study consisted of 653 eligible patients with Graves' disease. After receiving 131I radionuclide therapy, these patients were classified into the remission and non-remission groups. A logistic regression-based model was used to analyze independent factors affecting the patient response to 131I radionuclide therapy. The results showed that CTLA-4 49 A/G was closely related to the efficacy of 131 I treatment for Graves' disease (AG + GG vs. AA: OR = 6.543, 95%CI = 2.611 ∼ 16.40, P < 0.001; G vs. A: OR = 3.482, 95%CI = 2.457 ∼ 4.934, P < 0.001). Moreover, the findings revealed that haplotype A-C (P < 0.001, OR = 3.592, 95%CI: 2.451 ∼ 5.262) and G-C (P < 0.001, OR = 0.282, 95%CI: 0.204 ∼ 0.391) were associated with the efficacy of 131 I therapy in treating Graves' disease. Logistic regression analysis indicated that thyroid weight (OR = 0.963, 95%CI = 0.944 ∼ 0.982, P < 0.001) and CTLA-4 exon-1 49 A/G polymorphism (OR = 0.334, 95%CI = 0.233 ∼ 0.478, P < 0.001) independently affect the efficacy of 131 I therapy in Graves' disease. These data indicated that CTLA-4 exon-1 49 A/G polymorphism may be associated with patient response to radionuclide 131 I therapy in Graves' disease."xsd:string |
| http://purl.uniprot.org/citations/28776731 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.26327"xsd:string |
| http://purl.uniprot.org/citations/28776731 | http://purl.uniprot.org/core/author | "Hu B."xsd:string |
| http://purl.uniprot.org/citations/28776731 | http://purl.uniprot.org/core/author | "Lu J."xsd:string |
| http://purl.uniprot.org/citations/28776731 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/28776731 | http://purl.uniprot.org/core/author | "Zheng Y.L."xsd:string |
| http://purl.uniprot.org/citations/28776731 | http://purl.uniprot.org/core/author | "Wen X."xsd:string |
| http://purl.uniprot.org/citations/28776731 | http://purl.uniprot.org/core/author | "Zhang Z.F."xsd:string |
| http://purl.uniprot.org/citations/28776731 | http://purl.uniprot.org/core/author | "Wang Y.J."xsd:string |
| http://purl.uniprot.org/citations/28776731 | http://purl.uniprot.org/core/author | "Zhuang J."xsd:string |
| http://purl.uniprot.org/citations/28776731 | http://purl.uniprot.org/core/author | "Sun C.H."xsd:string |
| http://purl.uniprot.org/citations/28776731 | http://purl.uniprot.org/core/author | "Fan S.H."xsd:string |
| http://purl.uniprot.org/citations/28776731 | http://purl.uniprot.org/core/author | "Shan Q."xsd:string |
| http://purl.uniprot.org/citations/28776731 | http://purl.uniprot.org/core/author | "Li M.Q."xsd:string |
| http://purl.uniprot.org/citations/28776731 | http://purl.uniprot.org/core/author | "Wu D.M."xsd:string |
| http://purl.uniprot.org/citations/28776731 | http://purl.uniprot.org/core/author | "Bao Y.X."xsd:string |
| http://purl.uniprot.org/citations/28776731 | http://purl.uniprot.org/core/author | "Han X.R."xsd:string |
| http://purl.uniprot.org/citations/28776731 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/28776731 | http://purl.uniprot.org/core/name | "J Cell Biochem"xsd:string |
| http://purl.uniprot.org/citations/28776731 | http://purl.uniprot.org/core/pages | "6383-6390"xsd:string |
| http://purl.uniprot.org/citations/28776731 | http://purl.uniprot.org/core/title | "Correlations of CTLA-4 exon-1 49 A/G and promoter region 318C/T polymorphisms with the therapeutic efficacy of 131 I radionuclide in graves' disease in Chinese Han population."xsd:string |
| http://purl.uniprot.org/citations/28776731 | http://purl.uniprot.org/core/volume | "119"xsd:string |
| http://purl.uniprot.org/citations/28776731 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28776731 |
| http://purl.uniprot.org/citations/28776731 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28776731 |