| http://purl.uniprot.org/citations/28778798 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28778798 | http://www.w3.org/2000/01/rdf-schema#comment | "Patterning of the vertebrate eye into optic stalk, retinal pigment epithelium (RPE) and neural retina (NR) territories relies on a number of signaling pathways, but how these signals are interpreted by optic progenitors is not well understood. The primary cilium is a microtubule-based organelle that is essential for Hedgehog (Hh) signaling, but it has also been implicated in the regulation of other signaling pathways. Here, we show that the optic primordium is ciliated during early eye development and that ciliogenesis is essential for proper patterning and morphogenesis of the mouse eye. Ift172 mutants fail to generate primary cilia and exhibit patterning defects that resemble those of Gli3 mutants, suggesting that cilia are required to restrict Hh activity during eye formation. Ift122 mutants, which produce cilia with abnormal morphology, generate optic vesicles that fail to invaginate to produce the optic cup. These mutants also lack formation of the lens, RPE and NR. Such phenotypic features are accompanied by strong, ectopic Hh pathway activity, evidenced by altered gene expression patterns. Removal of GLI2 from Ift122 mutants rescued several aspects of optic cup and lens morphogenesis as well as RPE and NR specification. Collectively, our data suggest that proper assembly of primary cilia is critical for restricting the Hedgehog pathway during eye formation in the mouse."xsd:string |
| http://purl.uniprot.org/citations/28778798 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2017.07.012"xsd:string |
| http://purl.uniprot.org/citations/28778798 | http://purl.uniprot.org/core/author | "Burnett J.B."xsd:string |
| http://purl.uniprot.org/citations/28778798 | http://purl.uniprot.org/core/author | "Eggenschwiler J.T."xsd:string |
| http://purl.uniprot.org/citations/28778798 | http://purl.uniprot.org/core/author | "Lupu F.I."xsd:string |
| http://purl.uniprot.org/citations/28778798 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28778798 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/28778798 | http://purl.uniprot.org/core/pages | "32-40"xsd:string |
| http://purl.uniprot.org/citations/28778798 | http://purl.uniprot.org/core/title | "Proper ciliary assembly is critical for restricting Hedgehog signaling during early eye development in mice."xsd:string |
| http://purl.uniprot.org/citations/28778798 | http://purl.uniprot.org/core/volume | "430"xsd:string |
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