| http://purl.uniprot.org/citations/28784627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28784627 | http://www.w3.org/2000/01/rdf-schema#comment | "Myelopoiesis is necessary for the generation of mature myeloid cells during homeostatic turnover and immunological insults; however, the metabolic requirements for this process remain poorly defined. Here, we demonstrate that myelopoiesis, including monocyte and macrophage differentiation, requires mechanistic target of rapamycin complex 1 (mTORC1) signaling and anabolic metabolism. Loss of mTORC1 impaired myelopoiesis under steady state and dampened innate immune responses against Listeria monocytogenes infection. Stimulation of hematopoietic progenitors with macrophage colony-stimulating factor (M-CSF) resulted in mTORC1-dependent anabolic metabolism, which in turn promoted expression of M-CSF receptor and transcription factors PU.1 and IRF8, thereby constituting a feed-forward loop for myelopoiesis. Mechanistically, mTORC1 engaged glucose metabolism and initiated a transcriptional program involving Myc activation and sterol biosynthesis after M-CSF stimulation. Perturbation of glucose metabolism or disruption of Myc function or sterol biosynthesis impaired myeloid differentiation. Integrative metabolomic and genomic profiling further identified one-carbon metabolism as a central node in mTORC1-dependent myelopoiesis. Therefore, the interplay between mTORC1 signaling and metabolic reprogramming underlies M-CSF-induced myelopoiesis."xsd:string |
| http://purl.uniprot.org/citations/28784627 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20161855"xsd:string |
| http://purl.uniprot.org/citations/28784627 | http://purl.uniprot.org/core/author | "Chi H."xsd:string |
| http://purl.uniprot.org/citations/28784627 | http://purl.uniprot.org/core/author | "Neale G."xsd:string |
| http://purl.uniprot.org/citations/28784627 | http://purl.uniprot.org/core/author | "Vogel P."xsd:string |
| http://purl.uniprot.org/citations/28784627 | http://purl.uniprot.org/core/author | "Clish C.B."xsd:string |
| http://purl.uniprot.org/citations/28784627 | http://purl.uniprot.org/core/author | "Guy C."xsd:string |
| http://purl.uniprot.org/citations/28784627 | http://purl.uniprot.org/core/author | "Avila J."xsd:string |
| http://purl.uniprot.org/citations/28784627 | http://purl.uniprot.org/core/author | "Long L."xsd:string |
| http://purl.uniprot.org/citations/28784627 | http://purl.uniprot.org/core/author | "Karmaus P.W.F."xsd:string |
| http://purl.uniprot.org/citations/28784627 | http://purl.uniprot.org/core/author | "Herrada A.A."xsd:string |
| http://purl.uniprot.org/citations/28784627 | http://purl.uniprot.org/core/author | "Dhungana Y."xsd:string |
| http://purl.uniprot.org/citations/28784627 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28784627 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/28784627 | http://purl.uniprot.org/core/pages | "2629-2647"xsd:string |
| http://purl.uniprot.org/citations/28784627 | http://purl.uniprot.org/core/title | "Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF-mediated myelopoiesis."xsd:string |
| http://purl.uniprot.org/citations/28784627 | http://purl.uniprot.org/core/volume | "214"xsd:string |
| http://purl.uniprot.org/citations/28784627 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28784627 |
| http://purl.uniprot.org/citations/28784627 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28784627 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JDQ3-mappedCitation-28784627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28784627 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JFZ9-mappedCitation-28784627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28784627 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JEV4-mappedCitation-28784627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28784627 |
| http://purl.uniprot.org/uniprot/#_E0CZD1-mappedCitation-28784627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28784627 |
| http://purl.uniprot.org/uniprot/#_A0A991B922-mappedCitation-28784627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28784627 |