| http://purl.uniprot.org/citations/28793255 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28793255 | http://www.w3.org/2000/01/rdf-schema#comment | "The development and function of epithelia depend on the establishment and maintenance of cell-cell adhesion and intercellular junctions, which operate as mechanosensor hubs for the transduction of biochemical signals regulating cell proliferation, differentiation, survival, and regeneration. Here, we show that αE-catenin, a key component of adherens junctions, functions as a positive regulator of pancreatic islet cell lineage differentiation by repressing the sonic hedgehog pathway (SHH). Thus, deletion of αE-catenin in multipotent pancreatic progenitors resulted in (1) loss of adherens junctions, (2) constitutive activation of SHH, (3) decrease in islet cell lineage differentiation, and (4) accumulation of immature Sox9+ progenitors. Pharmacological blockade of SHH signaling in pancreatic organ cultures and in vivo rescued this defect, allowing αE-catenin-null Sox9+ pancreatic progenitors to differentiate into endocrine cells. The results uncover crucial functions of αE-catenin in pancreatic islet development and harbor significant implications for the design of β cell replacement and regeneration therapies in diabetes."xsd:string |
| http://purl.uniprot.org/citations/28793255 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2017.07.035"xsd:string |
| http://purl.uniprot.org/citations/28793255 | http://purl.uniprot.org/core/author | "Yang W."xsd:string |
| http://purl.uniprot.org/citations/28793255 | http://purl.uniprot.org/core/author | "Pillich R."xsd:string |
| http://purl.uniprot.org/citations/28793255 | http://purl.uniprot.org/core/author | "Meda P."xsd:string |
| http://purl.uniprot.org/citations/28793255 | http://purl.uniprot.org/core/author | "Diaferia G.R."xsd:string |
| http://purl.uniprot.org/citations/28793255 | http://purl.uniprot.org/core/author | "Cirulli V."xsd:string |
| http://purl.uniprot.org/citations/28793255 | http://purl.uniprot.org/core/author | "Crisa L."xsd:string |
| http://purl.uniprot.org/citations/28793255 | http://purl.uniprot.org/core/author | "Jimenez-Caliani A.J."xsd:string |
| http://purl.uniprot.org/citations/28793255 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28793255 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/28793255 | http://purl.uniprot.org/core/pages | "1295-1306"xsd:string |
| http://purl.uniprot.org/citations/28793255 | http://purl.uniprot.org/core/title | "alphaE-Catenin Is a Positive Regulator of Pancreatic Islet Cell Lineage Differentiation."xsd:string |
| http://purl.uniprot.org/citations/28793255 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/28793255 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28793255 |
| http://purl.uniprot.org/citations/28793255 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28793255 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVW7-mappedCitation-28793255 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28793255 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVX7-mappedCitation-28793255 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28793255 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWC4-mappedCitation-28793255 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28793255 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWZ4-mappedCitation-28793255 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28793255 |
| http://purl.uniprot.org/uniprot/#_D3Z7S6-mappedCitation-28793255 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28793255 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SUZ7-mappedCitation-28793255 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28793255 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVC9-mappedCitation-28793255 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28793255 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GXK7-mappedCitation-28793255 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28793255 |