| http://purl.uniprot.org/citations/28798028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28798028 | http://www.w3.org/2000/01/rdf-schema#comment | "In the thymus, hematopoietic progenitors commit to the T cell lineage and undergo sequential differentiation to generate diverse T cell subsets, including major histocompatibility complex (MHC)-restricted αβ T cell receptor (TCR) T cells and non-MHC-restricted γδ TCR T cells. The factors controlling precursor commitment and their subsequent maturation and specification into αβ TCR versus γδ TCR T cells remain unclear. Here, we show that the tyrosine phosphatase PTPN2 attenuates STAT5 (signal transducer and activator of transcription 5) signaling to regulate T cell lineage commitment and SRC family kinase LCK and STAT5 signaling to regulate αβ TCR versus γδ TCR T cell development. Our findings identify PTPN2 as an important regulator of critical checkpoints that dictate the commitment of multipotent precursors to the T cell lineage and their subsequent maturation into αβ TCR or γδ TCR T cells."xsd:string |
| http://purl.uniprot.org/citations/28798028 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20161903"xsd:string |
| http://purl.uniprot.org/citations/28798028 | http://purl.uniprot.org/core/author | "Godfrey D.I."xsd:string |
| http://purl.uniprot.org/citations/28798028 | http://purl.uniprot.org/core/author | "Boyd R.L."xsd:string |
| http://purl.uniprot.org/citations/28798028 | http://purl.uniprot.org/core/author | "Strasser A."xsd:string |
| http://purl.uniprot.org/citations/28798028 | http://purl.uniprot.org/core/author | "Dodd G.T."xsd:string |
| http://purl.uniprot.org/citations/28798028 | http://purl.uniprot.org/core/author | "Lu K.H."xsd:string |
| http://purl.uniprot.org/citations/28798028 | http://purl.uniprot.org/core/author | "Tiganis T."xsd:string |
| http://purl.uniprot.org/citations/28798028 | http://purl.uniprot.org/core/author | "Wiede F."xsd:string |
| http://purl.uniprot.org/citations/28798028 | http://purl.uniprot.org/core/author | "Butt T."xsd:string |
| http://purl.uniprot.org/citations/28798028 | http://purl.uniprot.org/core/author | "Dudakov J.A."xsd:string |
| http://purl.uniprot.org/citations/28798028 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28798028 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/28798028 | http://purl.uniprot.org/core/pages | "2733-2758"xsd:string |
| http://purl.uniprot.org/citations/28798028 | http://purl.uniprot.org/core/title | "PTPN2 regulates T cell lineage commitment and alphabeta versus gammadelta specification."xsd:string |
| http://purl.uniprot.org/citations/28798028 | http://purl.uniprot.org/core/volume | "214"xsd:string |
| http://purl.uniprot.org/citations/28798028 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28798028 |
| http://purl.uniprot.org/citations/28798028 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28798028 |
| http://purl.uniprot.org/uniprot/#_E9Q696-mappedCitation-28798028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28798028 |
| http://purl.uniprot.org/uniprot/#_A2A5D3-mappedCitation-28798028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28798028 |
| http://purl.uniprot.org/uniprot/#_A2A5D4-mappedCitation-28798028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28798028 |
| http://purl.uniprot.org/uniprot/#_B2C3G8-mappedCitation-28798028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28798028 |
| http://purl.uniprot.org/uniprot/#_B2KG65-mappedCitation-28798028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28798028 |
| http://purl.uniprot.org/uniprot/#_D3Z6W2-mappedCitation-28798028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28798028 |